Metalloproteinase Inhibitor 1 (TIMP1) Mouse Recombinant Protein

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. 1 Publication

Characterization and expression of a murine gene homologous to human EPA/TIMP a virus-induced gene in the mouse.Gewert D.R., Coulombe B., Castelino M., Skup D., Williams B.R.G.EMBO J. 6:651-657(1987) A growth-responsive gene (16C8) in normal mouse fibroblasts homologous to a human collagenase inhibitor with erythroid-potentiating activity evidence for inducible and constitutive transcripts.Edwards D.R., Waterhouse P., Holman M.L., Denhardt D.T.Nucleic Acids Res. 14:8863-8878(1986) Molecular cloning of gene sequences regulated by tumor promoters and mitogens through protein kinase C.Johnson M.D., Housey G.M., Kirschmeier P.T., Weinstein I.B.Mol. Cell. Biol. 7:2821-2829(1987) Genes for extracellular-matrix-degrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammalian development.Brenner C.A., Adler R.R., Rappolee D.A., Pedersen R.A., Werb Z.Genes Dev. 3:848-859(1989) Molecular cloning of partial cDNA copies of two distinct mouse IFN-beta mRNAs.Skup D., Windass J.D., Sor F.S., George H., Williams B.R., Fukuhara H., de Maeyer-Guignard J., de Maeyer E.Nucleic Acids Res. 10:3069-3084(1982) Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation.Toricelli M., Melo F.H., Peres G.B., Silva D.C., Jasiulionis M.G.Mol. Cancer 12:22-22(2013)

Small volumes of Timp1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS959921 is a recombinant protein targeting Timp1. Also known as Recombinant Mouse Metalloproteinase inhibitor 1. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.