Human IDS Recombinant Protein – Cat# MBS959987

Iduronate 2-Sulfatase (IDS) Human Recombinant Protein

Name: IDS Recombinant Protein; Iduronate 2-Sulfatase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS959987
Price: 1165 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS959987

Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter… More details

$1165 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Iduronate 2-sulfatase (IDS), Recombinant Protein

Full Product Name

Recombinant Human Iduronate 2-sulfatase (IDS)

Product Gene Name

IDS recombinant protein

Sequence

TDALNVLLII VDDLRPSLGC YGDKLVRSPN IDQLASHSLL FQNAFAQQAV CAPSRVSFLT GRRPDTTRLY DFNSYWRVHA GNFSTIPQYF KENGYVTMSV GKVFHPGISS NHTDDSPYSW SFPPYHPSSE KYENTKTCRG PDGELHANLL CPVDVLDVPE GTLPDKQSTE QAIQLLEKMK TSASPFFLAV GYHKPHIPFR YPKEFQKLYP LENITLAPDP EVPDGLPPVA YNPWMDIRQR EDVQALNISV PYGPIPVDFQ RKIRQSYFAS VSYLDTQVGR LLSALDDLQL ANSTIIAFTS DHGWALGEHG EWAKYSNFDV ATHVPLIFYV PGRTASLPEA GEKLFPYLDP FDSASQLMEP GRQSMDLVEL VSLFPTLAGL AGLQVPPRCP VPSFHVELCR EGKNLLKHFR FRDLEEDPYL PG

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

34,893 Da

Sequence Positions

34-455, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

300823

3D Structure

ModBase 3D Structure for P22304

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of IDS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IDS purchase

MBS959987 is a recombinant protein targeting IDS. Also known as Recombinant Human Iduronate 2-sulfatase (IDS). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for IDS. It may not necessarily be applicable to this product.

NCBI GI #

4557659

NCBI GeneID

3423

NCBI Accession #

NP_000193.1

UniProt Primary Accession #

P22304

UniProt Secondary Accession #

Q14604; Q9BRM3; D3DWT4

UniProt Related Accession #

P22304

GenBank Nucleotide #

NM_000202.7

NCBI Official Full Name

iduronate 2-sulfatase isoform a preproprotein

NCBI Official Synonym Full Names

iduronate 2-sulfatase

NCBI Official Symbol

IDS

NCBI Official Synonym Symbols

MPS2; SIDS

UniProt Protein Name

Iduronate 2-sulfatase

UniProt Synonym Protein Names

Alpha-L-iduronate sulfate sulfatase; Idursulfase

Protein Family

Iduronate 2-sulfatase

UniProt Gene Name

IDS

UniProt Synonym Gene Names

SIDS; Idursulfase

NCBI Protein Information

iduronate 2-sulfatase

NCBI Summary for IDS

This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

UniProt Comments for IDS

Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.

Research Articles on IDS

1. Study analyzed the genotype-phenotype relationship for 17 patients with mucopolysaccharidosis II and performed expression studies for 12 variants, nine of which have not been reported previously; speculated that very low or cell-type-specific IDS residual activity is sufficient to prevent the neuronal phenotype.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IDS recombinant protein

Reference Product	PubMed Publications
SET recombinant protein	>150 publications with IDS and SET
GNS recombinant protein	>1 publications with IDS and GNS
ARSJ recombinant protein	>1 publications with IDS and ARSJ
SUMF1 recombinant protein	>1 publications with IDS and SUMF1

Pathways associated with IDS recombinant protein

Products by Pathway	Pathway Diagram
CS/DS Degradation Pathway antibodies	CS/DS Degradation Pathway Diagram
Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies	Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
Dermatan Sulfate Degradation Pathway antibodies	Dermatan Sulfate Degradation Pathway Diagram
Dermatan Sulfate Degradation Pathway antibodies	Dermatan Sulfate Degradation Pathway Diagram
Glycosaminoglycan Degradation Pathway antibodies	Glycosaminoglycan Degradation Pathway Diagram
Glycosaminoglycan Degradation Pathway antibodies	Glycosaminoglycan Degradation Pathway Diagram
Glycosaminoglycan Metabolism Pathway antibodies	Glycosaminoglycan Metabolism Pathway Diagram
HS-GAG Degradation Pathway antibodies	HS-GAG Degradation Pathway Diagram
Heparan Sulfate Degradation Pathway antibodies	Heparan Sulfate Degradation Pathway Diagram
Heparan Sulfate Degradation Pathway antibodies	Heparan Sulfate Degradation Pathway Diagram

Diseases associated with IDS recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>430 publications with IDS and Nervous System Diseases
Mucopolysaccharidosis II Antibodies	>212 publications with IDS and Mucopolysaccharidosis II
Ovarian Neoplasms Antibodies	>76 publications with IDS and Ovarian Neoplasms
Ovarian Diseases Antibodies	>74 publications with IDS and Ovarian Diseases
Brain Diseases Antibodies	>66 publications with IDS and Brain Diseases
Inflammation Antibodies	>55 publications with IDS and Inflammation
Congenital Abnormalities Antibodies	>47 publications with IDS and Congenital Abnormalities
Disease Models, Animal Antibodies	>45 publications with IDS and Disease Models, Animal
Kidney Diseases Antibodies	>39 publications with IDS and Kidney Diseases
Lung Diseases Antibodies	>31 publications with IDS and Lung Diseases

Organs/Tissues associated with IDS recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>393 publications with IDS and Blood
Brain Antibodies	>130 publications with IDS and Brain
Bone Antibodies	>111 publications with IDS and Bone
Heart Antibodies	>88 publications with IDS and Heart
Muscle Antibodies	>68 publications with IDS and Muscle
Liver Antibodies	>61 publications with IDS and Liver
Vascular Antibodies	>50 publications with IDS and Vascular
Kidney Antibodies	>50 publications with IDS and Kidney
Skin Antibodies	>42 publications with IDS and Skin
Mouth Antibodies	>41 publications with IDS and Mouth