(Rhesus Macaque) Protransforming Growth Factor Alpha (TGFA) Macaca Mulatta Recombinant Protein

Function: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar

By similarity.

Subunit structure: Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2

By similarity.

Subcellular location: Transforming growth factor alpha: Secreted › extracellular space

By similarity. Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein

By similarity.

Tissue specificity: Hypothalamus. Ref.1

Developmental stage: Levels in the medial basal hypothalamus and preoptic area are elevated during neonatal life (1 week-6 months), decrease during juvenile development (8-18 months) and markedly increase during the expected time of puberty (30-36 months). Ref.1

Sequence similarities: Contains 1 EGF-like domain.