Apoptosis Regulator Bcl-2 (BCL2) Chicken Recombinant Protein

Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

Subunit structure: Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity

By similarity. Also interacts with APAF1 and RAF-1

By similarity.

Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Tissue specificity: In adult chicken expressed, in thymus, spleen, kidney, heart, ovary and brain, with the highest levels in the thymus. In the embryo, highly levels expressed in all tissues with high levels in the bursa of Fabricius.

Domain: The BH4 motif is required for anti-apoptotic activity and for interaction with RAF-1

By similarity.

Sequence similarities: Belongs to the Bcl-2 family.

Sequence caution: The sequence CAA78018.1 differs from that shown. Reason: Frameshift at positions 63 and 82.