Human BTC Recombinant Protein – Cat# MBS960653

Probetacellulin (BTC) Human Recombinant Protein

Name: BTC Recombinant Protein; Probetacellulin; Human; MyBioSource
Brand: MyBioSource
SKU: MBS960653
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS960653

Growth factor that binds to EGFR, ERBB4 and other EGF receptor family mbers. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Probetacellulin (BTC), Recombinant Protein

Full Product Name

Recombinant Human Probetacellulin (BTC)

Product Gene Name

BTC recombinant protein

Product Synonym Names

ProbetacellulinCleaved into the following chain:; 1. Betacellulin; 2. BTC

Sequence

DGNSTRSPET NGLLCGDPEE NCAATTTQSK RKGHFSRCPK QYKHYCIKGR CRFVVAEQTP SCVCDEGYIG ARCERVDLFY LRGDRGQILV ICLIAVMVVF IILVIGVCTC CHPLRKRRKR KKKEEEMETL GKDITPINED IEETNIA

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

18.6 kDa

Sequence Positions

32-178aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

600345

3D Structure

ModBase 3D Structure for P35070

Species

Homo sapiens (Human)

Product Categories/Family for BTC recombinant protein

Signal Transduction

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of BTC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BTC purchase

MBS960653 is a recombinant protein targeting BTC. Also known as Recombinant Human Probetacellulin (BTC). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for BTC. It may not necessarily be applicable to this product.

NCBI GI #

4502461

NCBI GeneID

685

NCBI Accession #

NP_001720.1

UniProt Primary Accession #

P35070

UniProt Secondary Accession #

Q96F48

UniProt Related Accession #

P35070

GenBank Nucleotide #

NM_001729.2

NCBI Official Full Name

probetacellulin

NCBI Official Synonym Full Names

betacellulin

NCBI Official Symbol

BTC

UniProt Protein Name

Probetacellulin

Protein Family

Probetacellulin

UniProt Gene Name

BTC

UniProt Synonym Gene Names

BTC

UniProt Entry Name

BTC_HUMAN

NCBI Protein Information

probetacellulin

NCBI Summary for BTC

The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor. [provided by RefSeq, Jul 2008]

UniProt Comments for BTC

BTC: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

Protein type: Ligand, receptor tyrosine kinase; Membrane protein, integral; Cell cycle regulation

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; plasma membrane; extracellular region; integral to membrane

Molecular Function: protein binding; growth factor activity; epidermal growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of fibroblast proliferation; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; positive regulation of mitosis; positive regulation of cell proliferation; innate immune response; positive regulation of cell differentiation; negative regulation of apoptosis

Research Articles on BTC

1. CXCL8 production from lung cancer cells could be initiated by an autocrine mechanism or external sources of BTC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BTC recombinant protein

Reference Product	PubMed Publications
EGFR recombinant protein	>56 publications with BTC and EGFR
ERBB2 recombinant protein	>34 publications with BTC and ERBB2
ERBB4 recombinant protein	>20 publications with BTC and ERBB4

Pathways associated with BTC recombinant protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies	Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies	Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
Downstream Signal Transduction Pathway antibodies	Downstream Signal Transduction Pathway Diagram
Downstream Signaling Of Activated FGFR Pathway antibodies	Downstream Signaling Of Activated FGFR Pathway Diagram
ErbB Receptor Signaling Network Pathway antibodies	ErbB Receptor Signaling Network Pathway Diagram
ErbB Signaling Pathway antibodies	ErbB Signaling Pathway Diagram

Diseases associated with BTC recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>171 publications with BTC and Neoplasms
Drug Toxicity Antibodies	>40 publications with BTC and Drug Toxicity
Liver Diseases Antibodies	>18 publications with BTC and Liver Diseases
Anemia Antibodies	>13 publications with BTC and Anemia
Necrosis Antibodies	>12 publications with BTC and Necrosis
Carcinoma, Hepatocellular Antibodies	>11 publications with BTC and Carcinoma, Hepatocellular
Breast Neoplasms Antibodies	>11 publications with BTC and Breast Neoplasms
Brain Diseases Antibodies	>7 publications with BTC and Brain Diseases
Neoplasm Metastasis Antibodies	>6 publications with BTC and Neoplasm Metastasis
Edema Antibodies	>6 publications with BTC and Edema

Organs/Tissues associated with BTC recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>48 publications with BTC and Liver
Ovary Antibodies	>25 publications with BTC and Ovary
Brain Antibodies	>16 publications with BTC and Brain
Kidney Antibodies	>11 publications with BTC and Kidney
Prostate Antibodies	>8 publications with BTC and Prostate
Connective Tissue Antibodies	>5 publications with BTC and Connective Tissue