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Urotensin-2 Receptor (UTS2R) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS960751

MBS960751 is a recombinant protein targeting Uts2r. Also known as Recombinant Rat Urotensin-2 receptor (Uts2r). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Urotensin-2 receptor (Uts2r), Recombinant Protein
Full Product Name
Recombinant Rat Urotensin-2 receptor (Uts2r)
Product Gene Name
Uts2r recombinant protein
Product Synonym Gene Name
Uts2r; Gpr14, Senr
Product Synonym Names
Recombinant Urotensin-2 receptor (Uts2r); Urotensin-2 receptor; UR-2-R; G-protein coupled receptor 14 G-protein coupled sensory epithelial neuropeptide-like receptor; SENR Urotensin II receptor; UR-II-R
Sequence
MALSLESTTS FHMLTVSGST VTELPGDSNV SLNSSWSGPT DPSSLKDLVA TGVIGAVLSA MGVVGMVGNV YTLVVMCRFL RASASMYVYV VNLALADLLY LLSIPFIIAT YVTKDWHFGD VGCRVLFSLD FLTMHASIFT LTIMSSERYA AVLRPLDTVQ RSKGYRKLLV LGTWLLALLL TLPMMLAIQL VRRGSKSLCL PAWGPRAHRT YLTLLFGTSI VGPGLVIGLL YVRLARAYWL SQQASFKQTR RLPNPRVLYL ILGIVLLFWA CFLPFWLWQL LAQYHEAMPL TPETARIVNY LTTCLTYGNS CINPFLYTLL TKNYREYLRG RQRSLGSSCH SPGSPGSFLP SRVHLQQDSG RSLSSSSQQA TETLMLSPVP RNGALL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
42,707 Da
Sequence Positions
1-386
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 10; NC_005109.3 (109951008..109952168). Location: 10q32.3
3D Structure
ModBase 3D Structure for P49684
Species
Rattus norvegicus (Rat)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Uts2r recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Uts2r. It may not necessarily be applicable to this product.

NCBI GI #
10120496
NCBI GeneID
57305
NCBI Accession #
NP_065412.1
UniProt Primary Accession #
P49684
UniProt Secondary Accession #
P48041
UniProt Related Accession #
P49684
GenBank Nucleotide #
NM_020537.1
NCBI Official Full Name
urotensin-2 receptor
NCBI Official Synonym Full Names
urotensin 2 receptor
NCBI Official Symbol
Uts2r
NCBI Official Synonym Symbols
Senr; Gpr14; UR-2-R
UniProt Protein Name
Urotensin-2 receptor
UniProt Synonym Protein Names
G-protein coupled receptor 14; G-protein coupled sensory epithelial neuropeptide-like receptor; SENR; Urotensin II receptor
Protein Family
Urotensin-2 receptor
UniProt Gene Name
Uts2r
UniProt Synonym Gene Names
Gpr14; Senr; UR-2-R; SENR; UR-II-R
UniProt Entry Name
UR2R_RAT
NCBI Protein Information
urotensin-2 receptor; UR-II-R; urotensin II receptor; G-protein coupled receptor 14; putative G protein-coupled receptor (SENR); G-protein coupled sensory epithelial neuropeptide-like receptor

NCBI Summary for Uts2r

G protein-coupled receptor isolated from retinal and taste cells [RGD, Feb 2006]

UniProt Comments for Uts2r

UTS2R: High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Cellular Component: recycling endosome; early endosome; integral to membrane; plasma membrane

Molecular Function: urotensin II receptor activity

Biological Process: response to drug; G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; positive regulation of fibroblast proliferation; elevation of cytosolic calcium ion concentration; positive regulation of circadian sleep/wake cycle, REM sleep; negative regulation of glomerular filtration; regulation of vasodilation; positive regulation of vasoconstriction; negative regulation of blood pressure; positive regulation of cell growth; positive regulation of blood pressure
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Research Articles on Uts2r

1. Data show that vasoactive peptide urotensin II receptor and GABA(A)R are co-expressed in cerebellar glial cells from rat brain slices, in human native astrocytes and in glioma cell line.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Uts2r recombinant protein

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram

Diseases associated with Uts2r recombinant protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >59 publications with Uts2r and Cardiovascular Diseases
 Heart Diseases Antibodies  >32 publications with Uts2r and Heart Diseases
 Hypertension Antibodies  >26 publications with Uts2r and Hypertension
 Kidney Diseases Antibodies  >20 publications with Uts2r and Kidney Diseases
 Neoplasms Antibodies  >15 publications with Uts2r and Neoplasms
 Myocardial Ischemia Antibodies  >11 publications with Uts2r and Myocardial Ischemia
 Atherosclerosis Antibodies  >11 publications with Uts2r and Atherosclerosis
 Hypertrophy Antibodies  >11 publications with Uts2r and Hypertrophy
 Liver Diseases Antibodies  >7 publications with Uts2r and Liver Diseases
 Diabetes Mellitus, Type 2 Antibodies  >7 publications with Uts2r and Diabetes Mellitus, Type 2
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