Activin Receptor Type-1c (ACVR1C) Rat Recombinant Protein

ALK7: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, TKL; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; EC 2.7.11.30; Kinase, protein; TKL group; STKR family; Type1 subfamily

Cellular Component: cell surface; cytoplasm; plasma membrane; activin receptor complex

Molecular Function: protein serine/threonine kinase activity; activin receptor activity, type I; metal ion binding; growth factor binding; activin binding; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: response to drug; transforming growth factor beta receptor complex assembly; response to dietary excess; in utero embryonic development; apoptosis; hippocampus development; activin receptor signaling pathway; positive regulation of caspase activity; response to lipid; protein amino acid phosphorylation; response to organic cyclic substance; negative regulation of insulin secretion; response to insulin stimulus; regulation of apoptosis; sequestering of lipid; ovarian follicle development; apoptotic nuclear changes; midbrain development; response to glucose stimulus; cerebellum development; determination of left/right symmetry; cell differentiation