Mouse TEAD2 Recombinant Protein – Cat# MBS961006

Transcriptional Enhancer Factor TEF-4 (TEAD2) Mouse Recombinant Protein

Name: TEAD2 Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS961006
Price: 1215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS961006

MBS961006 is a recombinant protein targeting Tead2. Also known as Recombinant Mouse Transcriptional enhancer factor TEF-4 (Tead2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1215 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Transcriptional enhancer factor TEF-4 (Tead2), Recombinant Protein

Full Product Name

Recombinant Mouse Transcriptional enhancer factor TEF-4 (Tead2)

Product Gene Name

Tead2 recombinant protein

Sequence

MGDPRTGAPL DDGGGWTGSE EGSEEGTGGS EGVGGDGSPD AEGVWSPDIE QSFQEALAIY PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARR KSREIQSKLK DQVSKDKAFQ TMATMSSAQL ISAPSLQAKL GPSGPQATEL FQFWSGSSGP PWNVPDVKPF SQAPFSVSLT PPASDLPGYE PPPALSPLPP PAPSPPAWQA RALGTARLQL IEFSAFVEPP DAVDSFQRHL FVHISQQCPS PGAPPLESVD VRQIYDKFPE KKGGLRELYD RGPPHAFFLV KFWADLNWGP SAEEAGSSGG GGGFYGVSSQ YESRELMTLT CSSKVCSFGK QVVEKVETER AQLEDGRFVY RLLRSPMCEY LVNFLHKLRQ LPERYMMNSV LENFTILQVV TNRDTQELLL CTAYVFEVST SERGAQYHIY RLVRD

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

49,041 Da

Sequence Positions

1-445aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P48301

Species

Mouse

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Tead2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Tead2. It may not necessarily be applicable to this product.

NCBI GI #

550821931

NCBI GeneID

21677

NCBI Accession #

NP_001272427.1

UniProt Primary Accession #

P48301

UniProt Secondary Accession #

Q62297

UniProt Related Accession #

P48301

GenBank Nucleotide #

NM_001285498.1

NCBI Official Full Name

transcriptional enhancer factor TEF-4 isoform a

NCBI Official Synonym Full Names

TEA domain family member 2

NCBI Official Symbol

Tead2

NCBI Official Synonym Symbols

ETF; Etdf; TEF4; TEF-4; TEAD-2

UniProt Protein Name

Transcriptional enhancer factor TEF-4

UniProt Synonym Protein Names

ETEF-1; Embryonic TEA domain-containing factor; ETF; TEA domain family member 2; TEAD-2

Protein Family

Transcriptional enhancer factor

UniProt Gene Name

Tead2

UniProt Synonym Gene Names

Etdf; Etf; Tef4; ETF; TEAD-2

NCBI Protein Information

transcriptional enhancer factor TEF-4

UniProt Comments for Tead2

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction (). Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

Research Articles on Tead2

1. Cells with reduced Tead activity became losers, whereas cells with increased Tead activity became super-competitors. Tead directly regulated Myc RNA expression, and cells with increased Myc expression also became super-competitors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Tead2 recombinant protein

Products by Pathway	Pathway Diagram
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies	Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
PPARA Activates Gene Expression Pathway antibodies	PPARA Activates Gene Expression Pathway Diagram
Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies	Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
YAP1- And WWTR1 (TAZ)-stimulated Gene Expression Pathway antibodies	YAP1- And WWTR1 (TAZ)-stimulated Gene Expression Pathway Diagram

Diseases associated with Tead2 recombinant protein

Disease Name	Pubmed Publications
Death Antibodies	>2 publications with Tead2 and Death

Organs/Tissues associated with Tead2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>9 publications with Tead2 and Embryonic Tissue
Brain Antibodies	>4 publications with Tead2 and Brain
Lung Antibodies	>3 publications with Tead2 and Lung
Uterus Antibodies	>1 publications with Tead2 and Uterus
Bone Antibodies	>1 publications with Tead2 and Bone
Spleen Antibodies	>1 publications with Tead2 and Spleen
Heart Antibodies	>1 publications with Tead2 and Heart
Skin Antibodies	>1 publications with Tead2 and Skin
Testis Antibodies	>1 publications with Tead2 and Testis
Kidney Antibodies	>1 publications with Tead2 and Kidney