Human NKX3-2 Recombinant Protein – Cat# MBS961103

Homeobox Protein Nkx-3.2 (NKX3-2) Human Recombinant Protein

Name: NKX3-2 Recombinant Protein; Homeobox Protein Nkx-3.2; Human; MyBioSource
Brand: MyBioSource
SKU: MBS961103
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS961103

Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the… More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Homeobox protein Nkx-3.2 (NKX3-2), Recombinant Protein

Full Product Name

Recombinant Human Homeobox protein Nkx-3.2 (NKX3-2)

Product Gene Name

NKX3-2 recombinant protein

Product Synonym Gene Name

NKX3-2; BAPX1; NKX3B

Product Synonym Names

Homeobox protein Nkx-3.2; Bagpipe homeobox protein homolog 1; Homeobox protein NK-3 homolog B

Sequence

MAVRGANTLT SFSIQAILNK KEERGGLAAP EGRPAPGGTA ASVAAAPAVC CWRLFGERDA GALGGAEDSL LASPAGTRTA AGRTAESPEG WDSDSALSEE NESRRRCADA RGASGAGLAG GSLSLGQPVC ELAASKDLEE EAAGRSDSEM SASVSGDRSP RTEDDGVGPR GAHVSALCSG AGGGGGSGPA GVAEEEEEPA APKPRKKRSR AAFSHAQVFE LERRFNHQRY LSGPERADLA ASLKLTETQV KIWFQNRRYK TKRRQMAADL LASAPAAKKV AVKVLVRDDQ RQYLPGEVLR PPSLLPLQPS YYYPYYCLPG WALSTCAAAA GTQ

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

34,814 Da

Sequence Positions

1-333, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

gene 613330

3D Structure

ModBase 3D Structure for P78367

Species

Homo sapiens (Human)

Production Note

Special Offer: The E. coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E. coli host-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E. coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E. coli host-expressed protein for the fastest delivery among all hosts. Please contact us or email to support@mybiosource.com for more details.

Product Categories/Family for NKX3-2 recombinant protein

Epigenetics and Nuclear Signaling/Epigenetics and Nuclear Signaling/Epigenetics and Nuclear Signaling

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NKX3-2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NKX3-2 purchase

MBS961103 is a recombinant protein targeting NKX3-2. Also known as Recombinant Human Homeobox protein Nkx-3.2 (NKX3-2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for NKX3-2. It may not necessarily be applicable to this product.

NCBI GI #

4502365

NCBI GeneID

579

NCBI Accession #

NP_001180.1

UniProt Primary Accession #

P78367

UniProt Secondary Accession #

Q2M2I7

UniProt Related Accession #

P78367

GenBank Nucleotide #

NM_001189.3

NCBI Official Full Name

homeobox protein Nkx-3.2

NCBI Official Synonym Full Names

NK3 homeobox 2

NCBI Official Symbol

NKX3-2

NCBI Official Synonym Symbols

SMMD; BAPX1; NKX3B; NKX3.2

UniProt Protein Name

Homeobox protein Nkx-3.2

UniProt Synonym Protein Names

Bagpipe homeobox protein homolog 1; Homeobox protein NK-3 homolog B

Protein Family

Homeobox protein

UniProt Gene Name

NKX3-2

UniProt Synonym Gene Names

BAPX1; NKX3B

UniProt Entry Name

NKX32_HUMAN

NCBI Protein Information

homeobox protein Nkx-3.2; homeobox protein NK-3 homolog B; bagpipe homeobox protein homolog 1

NCBI Summary for NKX3-2

This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008]

UniProt Comments for NKX3-2

NKX3-2: Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus. Defects in NKX3-2 are the cause of spondylo- megaepiphyseal-metaphyseal dysplasia (SMMD). It is a skeletal dysplasia characterized by disproportionate short stature with a short and stiff neck and trunk, relatively long limbs that may show flexion contractures of the distal joints, delayed and impaired ossification of the vertebral bodies, the presence of large epiphysea ossification centers and wide growth plates in the long tubular bones and numerous pseudoepiphyses of the short tubular bones in hands and feet. Belongs to the NK-3 homeobox family.

Protein type: Transcription factor; DNA-binding; Cell development/differentiation

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: nucleus

Biological Process: spleen development; transcription from RNA polymerase II promoter; organ formation; skeletal morphogenesis; embryonic skeletal development; pancreas development; negative regulation of chondrocyte differentiation; middle ear morphogenesis; negative regulation of transcription from RNA polymerase II promoter; determination of left/right symmetry; skeletal development; negative regulation of apoptosis

Disease: Spondylo-megaepiphyseal-metaphyseal Dysplasia

Research Articles on NKX3-2

1. Ihh-induced Nkx3.2 degradation requires Wnt5a, which is capable of triggering Nkx3.2 degradation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NKX3-2 recombinant protein

Reference Product	PubMed Publications
SHH recombinant protein	>12 publications with NKX3-2 and SHH
SMAD1 recombinant protein	>2 publications with NKX3-2 and SMAD1
SMAD4 recombinant protein	>1 publications with NKX3-2 and SMAD4
SIN3A recombinant protein	>1 publications with NKX3-2 and SIN3A
HDAC1 recombinant protein	>1 publications with NKX3-2 and HDAC1
SIX3 recombinant protein	>1 publications with NKX3-2 and SIX3

Pathways associated with NKX3-2 recombinant protein

Products by Pathway	Pathway Diagram
Endochondral Ossification Pathway antibodies	Endochondral Ossification Pathway Diagram

Diseases associated with NKX3-2 recombinant protein

Disease Name	Pubmed Publications
Hypertrophy Antibodies	>6 publications with NKX3-2 and Hypertrophy
Congenital Abnormalities Antibodies	>6 publications with NKX3-2 and Congenital Abnormalities
Disease Models, Animal Antibodies	>3 publications with NKX3-2 and Disease Models, Animal
Craniofacial Abnormalities Antibodies	>2 publications with NKX3-2 and Craniofacial Abnormalities
Spondylo-Megaepiphyseal-Metaphyseal Dysplasia Antibodies	>2 publications with NKX3-2 and Spondylo-Megaepiphyseal-Metaphyseal Dysplasia
Hyperplasia Antibodies	>1 publications with NKX3-2 and Hyperplasia
Inflammation Antibodies	>1 publications with NKX3-2 and Inflammation
Necrosis Antibodies	>1 publications with NKX3-2 and Necrosis

Organs/Tissues associated with NKX3-2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>15 publications with NKX3-2 and Embryonic Tissue