Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) Mouse Recombinant Protein

ALOX5AP: Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition. Belongs to the MAPEG family.

Protein type: Activator; Endoplasmic reticulum; Membrane protein, multi-pass; Membrane protein, integral; Nuclear envelope

Cellular Component: nuclear membrane; membrane; endoplasmic reticulum; integral to membrane; nuclear envelope; cytosol; nucleus

Molecular Function: arachidonic acid binding; protein binding; enzyme binding; protein homodimerization activity; protein heterodimerization activity; arachidonate 5-lipoxygenase activity; enzyme activator activity; protein N-terminus binding

Biological Process: leukotriene biosynthetic process; leukotriene production during acute inflammatory response; lipoxygenase pathway; positive regulation of acute inflammatory response; leukotriene metabolic process