Human ALDH7A1 Recombinant Protein – Cat# MBS961163

Alpha-Aminoadipic Semialdehyde Dehydrogenase (ALDH7A1) Human Recombinant Protein

Name: ALDH7A1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS961163
Price: 1315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS961163

Antiquitin is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a… More details

$1315 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1), Recombinant Protein

Full Product Name

Recombinant Human Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1)

Product Gene Name

ALDH7A1 recombinant protein

Sequence

AFMSTLLINQ PQYAWLKELG LREENEGVYN GSWGGRGEVI TTYCPANNEP IARVRQASVA DYEETVKKAR EAWKIWADIP APKRGEIVRQ IGDALREKIQ VLGSLVSLEM GKILVEGVGE VQEYVDICDY AVGLSRMIGG PILPSERSGH ALIEQWNPVG LVGIITAFNF PVAVYGWNNA IAMICGNVCL WKGAPTTSLI SVAVTKIIAK VLEDNKLPGA ICSLTCGGAD IGTAMAKDER VNLLSFTGST QVGKQVGLMV QERFGRSLLE LGGNNAIIAF EDADLSLVVP SALFAAVGTA GQRCTTARRL FIHESIHDEV VNRLKKAYAQ IRVGNPWDPN VLYGPLHTKQ AVSMFLGAVE EAKKEGGTVV YGGKVMDRPG NYVEPTIVTG LGHDASIAHT ETFAPILYVF KFKNEEEVFA WNNEVKQGLS SSIFTKDLGR IFRWLGPKGS DCGIVNVNIP TSGAEIGGAF GGEKHTGGGR ESGSDAWKQY MRRSTCTINY SKDLPLAQGI KFQ

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

51,411 Da

Sequence Positions

27-539, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

107323

3D Structure

ModBase 3D Structure for P49419

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ALDH7A1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALDH7A1 purchase

MBS961163 is a recombinant protein targeting ALDH7A1. Also known as Recombinant Human Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for ALDH7A1. It may not necessarily be applicable to this product.

NCBI GI #

188035924

NCBI GeneID

501

NCBI Accession #

NP_001173.2

UniProt Primary Accession #

P49419

UniProt Secondary Accession #

O14619; Q6IPU8; Q9BUL4; B2R669; B4DIC7; B4DMA0; E7EPT3

UniProt Related Accession #

P49419

GenBank Nucleotide #

NM_001182.4

NCBI Official Full Name

alpha-aminoadipic semialdehyde dehydrogenase isoform 1

NCBI Official Synonym Full Names

aldehyde dehydrogenase 7 family member A1

NCBI Official Symbol

ALDH7A1

NCBI Official Synonym Symbols

EPD; PDE; ATQ1

UniProt Protein Name

Alpha-aminoadipic semialdehyde dehydrogenase

UniProt Synonym Protein Names

Aldehyde dehydrogenase family 7 member A1 (EC:1.2.1.3); Antiquitin-1; Betaine aldehyde dehydrogenase (EC:1.2.1.8); Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase

Protein Family

Alpha-aminoadipic semialdehyde dehydrogenase

UniProt Gene Name

ALDH7A1

UniProt Synonym Gene Names

ATQ1; Alpha-AASA dehydrogenase; P6c dehydrogenase

NCBI Protein Information

alpha-aminoadipic semialdehyde dehydrogenase

NCBI Summary for ALDH7A1

The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified. [provided by RefSeq, Jan 2011]

UniProt Comments for ALDH7A1

Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.

Research Articles on ALDH7A1

1. Mutations in the ALDH7A1 gene encoding alpha-amino-adipic semialdehyde (alpha-AASA) dehydrogenase (antiquitin) have been identified as the cause of PDE. We report on a novel ALDH7A1 mutation in a Tunisian child with PDE.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ALDH7A1 recombinant protein

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Arginine And Proline Metabolism Pathway antibodies	Arginine And Proline Metabolism Pathway Diagram
Arginine And Proline Metabolism Pathway antibodies	Arginine And Proline Metabolism Pathway Diagram
Ascorbate And Aldarate Metabolism Pathway antibodies	Ascorbate And Aldarate Metabolism Pathway Diagram
Ascorbate And Aldarate Metabolism Pathway antibodies	Ascorbate And Aldarate Metabolism Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Fatty Acid Degradation Pathway antibodies	Fatty Acid Degradation Pathway Diagram
Fatty Acid Degradation Pathway antibodies	Fatty Acid Degradation Pathway Diagram
GABA Biosynthesis, Eukaryotes, Putrescine => GABA Pathway antibodies	GABA Biosynthesis, Eukaryotes, Putrescine => GABA Pathway Diagram
GABA Biosynthesis, Eukaryotes, Putrescine => GABA Pathway antibodies	GABA Biosynthesis, Eukaryotes, Putrescine => GABA Pathway Diagram

Diseases associated with ALDH7A1 recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>56 publications with ALDH7A1 and Nervous System Diseases
Brain Diseases Antibodies	>56 publications with ALDH7A1 and Brain Diseases
Seizures Antibodies	>52 publications with ALDH7A1 and Seizures
Pyridoxine-dependent epilepsy Antibodies	>46 publications with ALDH7A1 and Pyridoxine-dependent epilepsy
Disease Progression Antibodies	>6 publications with ALDH7A1 and Disease Progression
Bone Diseases Antibodies	>4 publications with ALDH7A1 and Bone Diseases
Lung Neoplasms Antibodies	>3 publications with ALDH7A1 and Lung Neoplasms
Neoplasm Metastasis Antibodies	>2 publications with ALDH7A1 and Neoplasm Metastasis
Cardiovascular Diseases Antibodies	>1 publications with ALDH7A1 and Cardiovascular Diseases
Inflammation Antibodies	>1 publications with ALDH7A1 and Inflammation

Organs/Tissues associated with ALDH7A1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>24 publications with ALDH7A1 and Brain
Blood Antibodies	>9 publications with ALDH7A1 and Blood
Kidney Antibodies	>6 publications with ALDH7A1 and Kidney
Liver Antibodies	>6 publications with ALDH7A1 and Liver
Ovary Antibodies	>4 publications with ALDH7A1 and Ovary
Lung Antibodies	>4 publications with ALDH7A1 and Lung
Eye Antibodies	>4 publications with ALDH7A1 and Eye
Bone Antibodies	>4 publications with ALDH7A1 and Bone
Prostate Antibodies	>3 publications with ALDH7A1 and Prostate
Ganglia Antibodies	>2 publications with ALDH7A1 and Ganglia