Human CES1 Recombinant Protein – Cat# MBS961237

Liver Carboxylesterase 1 (CES1) Human Recombinant Protein

Name: CES1 Recombinant Protein; Liver Carboxylesterase 1; Human; MyBioSource
Brand: MyBioSource
SKU: MBS961237
Price: 385 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS961237

Carboxylesterase 1 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and… More details

$385 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Liver carboxylesterase 1 (CES1), Recombinant Protein

Full Product Name

Recombinant Human Liver carboxylesterase 1 (CES1)

Product Gene Name

CES1 recombinant protein

Sequence

GHPSSPPVVD TVHGKVLGKF VSLEGFAQPV AIFLGIPFAK PPLGPLRFTP PQPAEPWSFV KNATSYPPMC TQDPKAGQLL SELFTNRKEN IPLKLSEDCL YLNIYTPADL TKKNRLPVMV WIHGGGLMVG AASTYDGLAL AAHENVVVVT IQYRLGIWGF FSTGDEHSRG NWGHLDQVAA LRWVQDNIAS FGGNPGSVTI FGESAGGESV SVLVLSPLAK NLFHRAISES GVALTSVLVK KGDVKPLAEQ IAITAGCKTT TSAVMVHCLR QKTEEELLET TLKMKFLSLD LQGDPRESQP LLGTVIDGML LLKTPEELQA ERNFHTVPYM VGINKQEFGW LIPMQLMSYP LSEGQLDQKT AMSLLWKSYP LVCIAKELIP EATEKYLGGT DDTVKKKDLF LDLIADVMFG VPSVIVARNH RDAGAPTYMY EFQYRPSFSS DMKPKTVIGD HGDELFSVFG APFLKEGASE EEIRLSKMVM KFWANFARNG NPNGEGLPHW PEYNQKEGYL QIGANTQAAQ KLKDKEVAFW TNLFAKKAVE KPPQTEHIEL

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

62,393 Da

Sequence Positions

18-567aa; Full Length of Mature Protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

114835

3D Structure

ModBase 3D Structure for P23141

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CES1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CES1 purchase

MBS961237 is a recombinant protein targeting CES1. Also known as Recombinant Human Liver carboxylesterase 1 (CES1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for CES1. It may not necessarily be applicable to this product.

NCBI GI #

68508965

NCBI GeneID

1066

NCBI Accession #

NP_001020365.1

UniProt Primary Accession #

P23141

UniProt Secondary Accession #

P82127; Q00015; Q13657; Q14062; Q16737; Q16788; Q549X7; A6NIM1; A8K3K8; A8K844; E9PAU8

UniProt Related Accession #

P23141

GenBank Nucleotide #

NM_001025194.1

NCBI Official Full Name

liver carboxylesterase 1 isoform b

NCBI Official Synonym Full Names

carboxylesterase 1

NCBI Official Symbol

CES1

NCBI Official Synonym Symbols

CEH; REH; TGH; ACAT; CE-1; CES2; HMSE; SES1; HMSE1; PCE-1; hCE-1

UniProt Protein Name

Liver carboxylesterase 1

UniProt Synonym Protein Names

Acyl-coenzyme A:cholesterol acyltransferase; ACAT; Brain carboxylesterase hBr1; Carboxylesterase 1 (EC:3.1.1.1

Protein Family

Liver carboxylesterase

UniProt Gene Name

CES1

UniProt Synonym Gene Names

CES2; SES1; REH; TGH

NCBI Protein Information

liver carboxylesterase 1

NCBI Summary for CES1

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

UniProt Comments for CES1

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.

Research Articles on CES1

1. Suggest a primary metabolic role for CES1 in the capacity of skin/keratinocytes to mediated biotransformation of penta-ethyl ester prodrug of DTPA.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CES1 recombinant protein

Products by Pathway	Pathway Diagram
Drug Metabolism - Other Enzymes Pathway antibodies	Drug Metabolism - Other Enzymes Pathway Diagram
Drug Metabolism - Other Enzymes Pathway antibodies	Drug Metabolism - Other Enzymes Pathway Diagram
E2F Transcription Factor Network Pathway antibodies	E2F Transcription Factor Network Pathway Diagram
Fluoropyrimidine Activity Pathway antibodies	Fluoropyrimidine Activity Pathway Diagram
Irinotecan Pathway antibodies	Irinotecan Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram

Diseases associated with CES1 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>13 publications with CES1 and Neoplasms
Liver Diseases Antibodies	>10 publications with CES1 and Liver Diseases
Drug Toxicity Antibodies	>8 publications with CES1 and Drug Toxicity
Carcinoma Antibodies	>7 publications with CES1 and Carcinoma
Liver Neoplasms Antibodies	>7 publications with CES1 and Liver Neoplasms
Adenocarcinoma Antibodies	>6 publications with CES1 and Adenocarcinoma
Obesity Antibodies	>6 publications with CES1 and Obesity
Influenza, Human Antibodies	>5 publications with CES1 and Influenza, Human
Atherosclerosis Antibodies	>5 publications with CES1 and Atherosclerosis
Hepatitis Antibodies	>5 publications with CES1 and Hepatitis

Organs/Tissues associated with CES1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>51 publications with CES1 and Liver
Intestine Antibodies	>20 publications with CES1 and Intestine
Blood Antibodies	>12 publications with CES1 and Blood
Adipose Tissue Antibodies	>4 publications with CES1 and Adipose Tissue
Kidney Antibodies	>4 publications with CES1 and Kidney
Connective Tissue Antibodies	>4 publications with CES1 and Connective Tissue
Lung Antibodies	>4 publications with CES1 and Lung
Brain Antibodies	>2 publications with CES1 and Brain
Stomach Antibodies	>2 publications with CES1 and Stomach
Bone Antibodies	>2 publications with CES1 and Bone