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Granzyme A (GZMA) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS961731

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface nonself antigens, usually peptides or… More details

$900 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Granzyme A (GZMA), Recombinant Protein
Full Product Name
Recombinant Human Granzyme A (GZMA)
Product Gene Name
GZMA recombinant protein
Sequence
IIGGNEVTPH SRPYMVLLSL DRKTICAGAL IAKDWVLTAA HCNLNKRSQV ILGAHSITRE EPTKQIMLVK KEFPYPCYDP ATREGDLKLL QLMEKAKINK YVTILHLPKK GDDVKPGTMC QVAGWGRTHN SASWSDTLRE VNITIIDRKV CNDRNHYNFN PVIGMNMVCA GSLRGGRDSC NGDSGSPLLC EGVFRGVTSF GLENKCGDPR GPGVYILLSK KHLNWIIMTI KGAV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
27,109 Da
Sequence Positions
29-262, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
140050
3D Structure
ModBase 3D Structure for P12544
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of GZMA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GZMA purchase

MBS961731 is a recombinant protein targeting GZMA. Also known as Recombinant Human Granzyme A (GZMA). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for GZMA. It may not necessarily be applicable to this product.

NCBI GI #
5453676
NCBI GeneID
3001
NCBI Accession #
NP_006135.1
UniProt Primary Accession #
P12544
UniProt Secondary Accession #
Q6IB36; A4PHN1
UniProt Related Accession #
P12544
GenBank Nucleotide #
NM_006144.3
NCBI Official Full Name
granzyme A
NCBI Official Synonym Full Names
granzyme A
NCBI Official Symbol
GZMA
NCBI Official Synonym Symbols
HFSP; CTLA3
UniProt Protein Name
Granzyme A
UniProt Synonym Protein Names
CTL tryptase; Cytotoxic T-lymphocyte proteinase 1; Fragmentin-1; Granzyme-1; Hanukkah factor; H factor; HF
Protein Family
Granzyme
UniProt Gene Name
GZMA
UniProt Synonym Gene Names
CTLA3; HFSP; H factor; HF
NCBI Protein Information
granzyme A

NCBI Summary for GZMA

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]
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UniProt Comments for GZMA

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
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Research Articles on GZMA

1. granzyme A in human platelets increases with aging

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GZMA recombinant protein

 Reference Product  PubMed Publications
 PRF1 recombinant protein  >140 publications with GZMA and PRF1
 GZMK recombinant protein  >11 publications with GZMA and GZMK
 GNLY recombinant protein  >6 publications with GZMA and GNLY
 IL2 recombinant protein  >2 publications with GZMA and IL2

Pathways associated with GZMA recombinant protein

 Products by Pathway  Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with GZMA recombinant protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >32 publications with GZMA and Necrosis
 Inflammation Antibodies  >15 publications with GZMA and Inflammation
 Disease Models, Animal Antibodies  >7 publications with GZMA and Disease Models, Animal
 Drug Toxicity Antibodies  >5 publications with GZMA and Drug Toxicity
 Hypersensitivity Antibodies  >5 publications with GZMA and Hypersensitivity
 Gastrointestinal Diseases Antibodies  >5 publications with GZMA and Gastrointestinal Diseases
 Lung Diseases Antibodies  >4 publications with GZMA and Lung Diseases
 Blood Coagulation Disorders Antibodies  >3 publications with GZMA and Blood Coagulation Disorders
 Liver Diseases Antibodies  >3 publications with GZMA and Liver Diseases
 Kidney Diseases Antibodies  >2 publications with GZMA and Kidney Diseases

Organs/Tissues associated with GZMA recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >261 publications with GZMA and Blood
 Lung Antibodies  >10 publications with GZMA and Lung
 Skin Antibodies  >10 publications with GZMA and Skin
 Spleen Antibodies  >9 publications with GZMA and Spleen
 Kidney Antibodies  >9 publications with GZMA and Kidney
 Heart Antibodies  >8 publications with GZMA and Heart
 Intestine Antibodies  >8 publications with GZMA and Intestine
 Uterus Antibodies  >5 publications with GZMA and Uterus
 Lymph Node Antibodies  >5 publications with GZMA and Lymph Node
 Brain Antibodies  >3 publications with GZMA and Brain
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