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5-Hydroxytryptamine Receptor 2b (HTR2B) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS961791

MBS961791 is a recombinant protein targeting Htr2b. Also known as Recombinant Rat 5-hydroxytryptamine receptor 2B (Htr2b). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
5-hydroxytryptamine receptor 2B (Htr2b), Recombinant Protein
Full Product Name
Recombinant Rat 5-hydroxytryptamine receptor 2B (Htr2b)
Product Gene Name
Htr2b recombinant protein
Product Synonym Gene Name
Htr2b; Srl
Product Synonym Names
Recombinant 5-hydroxytryptamine receptor 2B (Htr2b); 5-hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT2B; 5-HT-2F Serotonin receptor 2B Stomach fundus serotonin receptor
Sequence
MASSYKMSEQ STISEHILQK TCDHLILTDR SGLKAESAAE EMKQTAENQG NTVHWAALLI FAVIIPTIGG NILVILAVSL EKRLQYATNY FLMSLAVADL LVGLFVMPIA LLTIMFEATW PLPLALCPAW LFLDVLFSTA SIMHLCAISL DRYIAIKKPI QANQCNSRTT AFVKITVVWL ISIGIAIPVP IKGIEADVVN AHNITCELTK DRFGSFMLFG SLAAFFAPLT IMIVTYFLTI HALRKKAYLV RNRPPQRLTR WTVSTVLQRE DSSFSSPEKM VMLDGSHKDK ILPNSTDETL MRRMSSAGKK PAQTISNEQR ASKVLGIVFL FFLLMWCPFF ITNVTLALCD SCNQTTLKTL LQIFVWVGYV SSGVNPLIYT LFNKTFREAF GRYITCNYQA TKSVKVLRKC SSTLYFGNSM VENSKFFTKH GIRNGINPAM YQSPVRLRSS TIQSSSIILL NTFLTENDGD KVEDQVSYI
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
53,652 Da
Sequence Positions
1-479
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 9; NC_005108.3 (92842573..92854806, complement). Location: 9q35
3D Structure
ModBase 3D Structure for P30994
Species
Rattus norvegicus (Rat)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Htr2b recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Htr2b. It may not necessarily be applicable to this product.

NCBI GI #
8393586
NCBI GeneID
29581
NCBI Accession #
NP_058946.1
UniProt Primary Accession #
P30994
UniProt Secondary Accession #
Q9QW44
UniProt Related Accession #
P30994
GenBank Nucleotide #
NM_017250.1
NCBI Official Full Name
5-hydroxytryptamine receptor 2B
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
NCBI Official Symbol
Htr2b
UniProt Protein Name
5-hydroxytryptamine receptor 2B
UniProt Synonym Protein Names
5-HT-2F; Serotonin receptor 2B; Stomach fundus serotonin receptor
UniProt Gene Name
Htr2b
UniProt Synonym Gene Names
Srl; 5-HT-2B; 5-HT2B
UniProt Entry Name
5HT2B_RAT
NCBI Protein Information
5-hydroxytryptamine receptor 2B; 5-HT2B; 5-HT-2B; 5-HT-2F; serotonin receptor 2B; stomach fundus serotonin receptor

NCBI Summary for Htr2b

G-protein coupled receptor for serotonin [RGD, Feb 2006]

UniProt Comments for Htr2b

5-HT(2B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Cellular Component: neuron projection; membrane; cell soma; integral to plasma membrane; dendrite; cytoplasm; plasma membrane; synapse; intracellular; cell junction

Molecular Function: protein binding; serotonin binding; serotonin receptor activity; G-protein alpha-subunit binding; drug binding

Biological Process: heart morphogenesis; cGMP biosynthetic process; negative regulation of autophagy; phosphoinositide 3-kinase cascade; inositol phosphate metabolic process; intestine smooth muscle contraction; heart development; positive regulation of MAP kinase activity; positive regulation of cell proliferation; protein kinase C activation; neural crest cell differentiation; embryonic morphogenesis; neural crest cell migration; serotonin receptor signaling pathway; regulation of behavior; positive regulation of cytokine production; response to drug; vasoconstriction; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of nitric-oxide synthase activity; calcium-mediated signaling; positive regulation of phosphatidylinositol biosynthetic process; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; G-protein coupled receptor internalization; phospholipase C activation; release of sequestered calcium ion into cytosol; positive regulation of cell division; positive regulation of endothelial cell proliferation; phosphorylation; positive regulation of cytokine secretion; negative regulation of apoptosis
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Research Articles on Htr2b

1. The opposing effects of serotonin, mediated by distinct 5-HT receptors, could explain why drugs targeting serotonin function can cause either diabetes or hypoglycemia in humans.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Htr2b recombinant protein

 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram

Diseases associated with Htr2b recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with Htr2b and Nervous System Diseases
 Brain Diseases Antibodies  >3 publications with Htr2b and Brain Diseases
 Obesity Antibodies  >3 publications with Htr2b and Obesity
 Mental Disorders Antibodies  >3 publications with Htr2b and Mental Disorders
 Serotonin Syndrome Antibodies  >2 publications with Htr2b and Serotonin Syndrome
 Neurologic Manifestations Antibodies  >1 publications with Htr2b and Neurologic Manifestations
 Liver Diseases Antibodies  >1 publications with Htr2b and Liver Diseases
 Migraine Disorders Antibodies  >1 publications with Htr2b and Migraine Disorders
 Obsessive-Compulsive Disorder Antibodies  >1 publications with Htr2b and Obsessive-Compulsive Disorder
 Anxiety Disorders Antibodies  >1 publications with Htr2b and Anxiety Disorders
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