Mouse KCNQ1 Recombinant Protein – Cat# MBS961931

Potassium Voltage-Gated Channel Subfamily KQT Member 1 (KCNQ1) Mouse Recombinant Protein

Name: KCNQ1 Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS961931
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS961931

MBS961931 is a recombinant protein targeting Kcnq1. Also known as Recombinant Mouse Potassium voltage-gated channel subfamily KQT member 1 (Kcnq1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Potassium voltage-gated channel subfamily KQT member 1 (Kcnq1), Recombinant Protein

Full Product Name

Recombinant Mouse Potassium voltage-gated channel subfamily KQT member 1 (Kcnq1)

Product Gene Name

Kcnq1 recombinant protein

Product Synonym Gene Name

Kcnq1; Kcna9, Kvlqt1

Product Synonym Names

Recombinant Potassium voltage-gated channel subfamily KQT member 1 (Kcnq1); Potassium voltage-gated channel subfamily KQT member 1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 KQT-like 1 Voltage-gated potassium channel subunit

Sequence

MDTASSPPSA ERKRAGWSRL LGARRGSAVV KKCPFSLELA EGGPEGSTVY APIAPTGAPG LAPPMSTPVS PAPAPADLGP RPRVSLDPRV SIYSARRPLL ARTHIQGRVY NFLERPTGWK CFVYHFTVFL IVLVCLIFSV LSTIEQYAAL ATGTLFWMEI VLVVFFGTEY VVRLWSAGCR SKYVGIWGRL RFARKPISII DLIVVVASMV VLCVGSKGQV FATSAIRGIR FLQILRMLHV DRQGGTWRLL GSVVFIHRQE LITTLYIGFL GLIFSSYFVY LAEKDAVNES GRIEFGSYAD ALWWGVVTVT TIGYGDKVPQ TWVGKTIASC FSVFAISFFA LPAGILGSGF ALKVQQKQRQ KHFNRQIPAA ASLIQTAWRC YAAENPDSAT WKIYVRKPAR SHTLLSPSPK PKKSVMVKKK KFKLDKDNGM SPGEKMFNVP HITYDPPEDR RPDHFSIDGY DSSVRKSPTL LEVSTPHFLR TNSFAEDLDL EGETLLTPIT HVSQLRDHHR ATIKVIRRMQ YFVAKKKFQQ ARKPYDVRDV IEQYSQGHLN LMVRIKELQR RLDQSIGKPS LFIPISEKSK DRGSNTIGAR LNRVEDKVTQ LDQRLVIITD MLHQLLSMQQ GGPTCNSRSQ VVASNEGGSI NPELFLPSNS LPTYEQLTVP QTGPDEGS

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

74,514 Da

Sequence Positions

1-668

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 7; NC_000073.6 (143107254..143427042). Location: 7 F5; 7 88.12 cM

3D Structure

ModBase 3D Structure for P97414

Species

Mus musculus (Mouse)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Kcnq1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Kcnq1. It may not necessarily be applicable to this product.

NCBI GI #

70887795

NCBI GeneID

16535

NCBI Accession #

NP_032460.2

UniProt Primary Accession #

P97414

UniProt Secondary Accession #

O88702; Q3U4H1; Q7TNZ1; Q7TPL7; Q80VR7

UniProt Related Accession #

P97414

GenBank Nucleotide #

NM_008434.2

NCBI Official Full Name

potassium voltage-gated channel subfamily KQT member 1

NCBI Official Synonym Full Names

potassium voltage-gated channel, subfamily Q, member 1

NCBI Official Symbol

Kcnq1

NCBI Official Synonym Symbols

Kcna9; KVLQT1; AW559127

UniProt Protein Name

Potassium voltage-gated channel subfamily KQT member 1

UniProt Synonym Protein Names

IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1

Protein Family

Potassium voltage-gated channel subfamily

UniProt Gene Name

Kcnq1

UniProt Synonym Gene Names

Kcna9; Kvlqt1

UniProt Entry Name

KCNQ1_MOUSE

NCBI Protein Information

potassium voltage-gated channel subfamily KQT member 1; KQT-like 1; voltage-gated potassium channel subunit Kv7.1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1

UniProt Comments for Kcnq1

Kv7.1: a voltage-gated potassium channel protein required for the repolarization phase of the cardiac action potential. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea. Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries. Three alternatively spliced isoforms have been described.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium

Cellular Component: voltage-gated potassium channel complex; zymogen granule membrane; cytoplasmic vesicle membrane; membrane; basolateral plasma membrane; lysosome; integral to plasma membrane; late endosome; early endosome; integral to membrane; plasma membrane; cytoplasmic vesicle; sarcolemma

Molecular Function: calmodulin binding; voltage-gated potassium channel activity; protein homodimerization activity; potassium channel activity; outward rectifier potassium channel activity; delayed rectifier potassium channel activity; ion channel activity; voltage-gated ion channel activity; protein phosphatase 1 binding

Biological Process: regulation of membrane potential; genetic imprinting; transport; ion transport; positive regulation of heart rate; gene silencing; transmembrane transport; potassium ion transport; cardiac muscle contraction; negative regulation of insulin secretion

Research Articles on Kcnq1

1. KCNE2 influences blood-CSF anion flux by regulating KCNQ1 and KCNA3 in the choroid plexus epithelium.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Kcnq1 recombinant protein

Products by Pathway	Pathway Diagram
Cholinergic Synapse Pathway antibodies	Cholinergic Synapse Pathway Diagram
Gastric Acid Secretion Pathway antibodies	Gastric Acid Secretion Pathway Diagram
Gastric Acid Secretion Pathway antibodies	Gastric Acid Secretion Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Pancreatic Secretion Pathway antibodies	Pancreatic Secretion Pathway Diagram
Pancreatic Secretion Pathway antibodies	Pancreatic Secretion Pathway Diagram
Potassium Channels Pathway antibodies	Potassium Channels Pathway Diagram
Protein Digestion And Absorption Pathway antibodies	Protein Digestion And Absorption Pathway Diagram
Protein Digestion And Absorption Pathway antibodies	Protein Digestion And Absorption Pathway Diagram
SIDS Susceptibility Pathways antibodies	SIDS Susceptibility Pathways Diagram

Diseases associated with Kcnq1 recombinant protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>535 publications with Kcnq1 and Cardiovascular Diseases
Arrhythmias, Cardiac Antibodies	>532 publications with Kcnq1 and Arrhythmias, Cardiac
Heart Diseases Antibodies	>524 publications with Kcnq1 and Heart Diseases
Long QT Syndrome Antibodies	>505 publications with Kcnq1 and Long QT Syndrome
Death, Sudden, Cardiac Antibodies	>208 publications with Kcnq1 and Death, Sudden, Cardiac
Syncope Antibodies	>101 publications with Kcnq1 and Syncope
Tachycardia Antibodies	>74 publications with Kcnq1 and Tachycardia
Tachycardia, Ventricular Antibodies	>70 publications with Kcnq1 and Tachycardia, Ventricular
Romano-Ward Syndrome Antibodies	>69 publications with Kcnq1 and Romano-Ward Syndrome
Heart Arrest Antibodies	>68 publications with Kcnq1 and Heart Arrest