Human CSNK1A1 Recombinant Protein – Cat# MBS962778

Casein Kinase I Isoform Alpha (CSNK1A1) Human Recombinant Protein

Name: CSNK1A1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS962778
Price: 385 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS962778

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate… More details

$385 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Casein kinase I isoform alpha (CSNK1A1), Recombinant Protein

Full Product Name

Recombinant Human Casein kinase I isoform alpha

Product Gene Name

CSNK1A1 recombinant protein

Product Synonym Names

CK1

Sequence

ASSSGSKAEF IVGGKYKLVR KIGSGSFGDI YLAINITNGE EVAVKLESQK ARHPQLLYES KLYKILQGGV GIPHIRWYGQ EKDYNVLVMD LLGPSLEDLF NFCSRRFTMK TVLMLADQMI SRIEYVHTKN FIHRDIKPDN FLMGIGRHCN KLFLIDFGLA KKYRDNRTRQ HIPYREDKNL TGTARYASIN AHLGIEQSRR DDMESLGYVL MYFNRTSLPW QGLKAATKKQ KYEKISEKKM STPVEVLCKG FPAEFAMYLN YCRGLRFEEA PDYMYLRQLF RILFRTLNHQ YDYTFDWTML KQKAAQQAAS SSGQGQQAQT PTGKQTDKTK SNMKGF

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

42.8 kDa

Sequence Positions

2-337aa; Full Length of Mature Protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

600505

3D Structure

ModBase 3D Structure for P48729

Product Categories/Family for CSNK1A1 recombinant protein

Cell Cycle

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for CSNK1A1 recombinant protein

Cloning and chromosomal localization of the gene coding for human protein kinase CK1.Tapia C., Featherstone T., Gomez C., Taillon-Miller P., Allende C.C., Allende J.E.FEBS Lett. 349:307-312(1994)

Other Notes

Small volumes of CSNK1A1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CSNK1A1 purchase

MBS962778 is a recombinant protein targeting CSNK1A1. Also known as Recombinant Human Casein kinase I isoform alpha. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for CSNK1A1. It may not necessarily be applicable to this product.

NCBI GI #

68303575

NCBI GeneID

1452

NCBI Accession #

NP_001020276.1

UniProt Primary Accession #

P48729

UniProt Secondary Accession #

Q4JJA0; Q5U046; Q5U047; Q6FGA2; Q71TU5; Q96HD2; Q9UDK3; D3DQG0; D3DQG1

UniProt Related Accession #

P48729

GenBank Nucleotide #

NM_001025105.2

NCBI Official Full Name

casein kinase I isoform alpha isoform 1

NCBI Official Synonym Full Names

casein kinase 1 alpha 1

NCBI Official Symbol

CSNK1A1

NCBI Official Synonym Symbols

CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p

UniProt Protein Name

Casein kinase I isoform alpha

UniProt Synonym Protein Names

CK1

Protein Family

Casein kinase

UniProt Gene Name

CSNK1A1

UniProt Synonym Gene Names

CKI-alpha

UniProt Entry Name

KC1A_HUMAN

NCBI Protein Information

casein kinase I isoform alpha

UniProt Comments for CSNK1A1

CK1A: an ubiquitous protein kinase of the CK1 family. Participates in Wnt signaling. Phosphorylates beta catenin, marking it for beta-TRCp-mediated ubiquitinylation and proteasomal degradation.

Protein type: EC 2.7.11.1; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CK1 group; CK1 family

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: beta-catenin destruction complex; centrosome; cytosol; keratin filament; membrane; mRNA cleavage and polyadenylation specificity factor complex; nuclear speck; ribonucleoprotein complex

Molecular Function: ATP binding; protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: cell division; cell morphogenesis; cell surface receptor linked signal transduction; Golgi organization and biogenesis; intermediate filament cytoskeleton organization and biogenesis; mitosis; peptidyl-serine phosphorylation; phagocytosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; signal transduction; Wnt receptor signaling pathway

Research Articles on CSNK1A1

1. characterization of frequency and potential clinical impact of CSNK1A1 mutations in myelodysplastic syndrome(MDS) and acute myeloid leukemia following MDS in a large cohort of patients

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CSNK1A1 recombinant protein

Products by Pathway	Pathway Diagram
AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies	AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies	APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies	AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies	AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
Activation Of SMO Pathway antibodies	Activation Of SMO Pathway Diagram
Beta-catenin Phosphorylation Cascade Pathway antibodies	Beta-catenin Phosphorylation Cascade Pathway Diagram
Canonical Wnt Signaling Pathway antibodies	Canonical Wnt Signaling Pathway Diagram
Degradation Of GLI2 By The Proteasome Pathway antibodies	Degradation Of GLI2 By The Proteasome Pathway Diagram
Degradation Of Beta-catenin By The Destruction Complex Pathway antibodies	Degradation Of Beta-catenin By The Destruction Complex Pathway Diagram
Disassembly Of The Destruction Complex And Recruitment Of AXIN To The Membrane Pathway antibodies	Disassembly Of The Destruction Complex And Recruitment Of AXIN To The Membrane Pathway Diagram

Diseases associated with CSNK1A1 recombinant protein

Disease Name	Pubmed Publications
Cell Transformation, Neoplastic Antibodies	>2 publications with CSNK1A1 and Cell Transformation, Neoplastic
Disease Models, Animal Antibodies	>1 publications with CSNK1A1 and Disease Models, Animal
Cognition Disorders Antibodies	>1 publications with CSNK1A1 and Cognition Disorders
Anemia Antibodies	>1 publications with CSNK1A1 and Anemia
Hyperplasia Antibodies	>1 publications with CSNK1A1 and Hyperplasia
Inflammation Antibodies	>1 publications with CSNK1A1 and Inflammation
Leukemia-Lymphoma, Adult T-Cell Antibodies	>1 publications with CSNK1A1 and Leukemia-Lymphoma, Adult T-Cell

Organs/Tissues associated with CSNK1A1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>5 publications with CSNK1A1 and Lung
Bone Antibodies	>3 publications with CSNK1A1 and Bone
Brain Antibodies	>2 publications with CSNK1A1 and Brain
Lymph Node Antibodies	>1 publications with CSNK1A1 and Lymph Node
Intestine Antibodies	>1 publications with CSNK1A1 and Intestine
Skin Antibodies	>1 publications with CSNK1A1 and Skin
Prostate Antibodies	>1 publications with CSNK1A1 and Prostate