Phosphatidylcholine:ceramide Cholinephosphotransferase 1 (SGMS1) Pig Recombinant Protein

Function: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide

By similarity.

Catalytic activity: A ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol.

Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein

By similarity.

Tissue specificity: Widely expressed. Highest expression in the cardiovascular system. Ref.1

Sequence similarities: Belongs to the sphingomyelin synthase family.Contains 1 SAM (sterile alpha motif) domain.

Sequence caution: The sequence CAJ81057.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.