Human DNAJA1 Recombinant Protein – Cat# MBS963177

Dnaj Homolog Subfamily A Member 1 (DNAJA1) Human Recombinant Protein

Name: DNAJA1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS963177
Price: 500 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS963177

MBS963177 is a recombinant protein targeting DNAJA1. Also known as Recombinant Human DnaJ homolog subfamily A member 1 (DNAJA1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$500 / 0.02 mg (Yeast) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DnaJ homolog subfamily A member 1 (DNAJA1), Recombinant Protein

Full Product Name

Recombinant Human DnaJ homolog subfamily A member 1 (DNAJA1)

Product Gene Name

DNAJA1 recombinant protein

Sequence

MVKETTYYDV LGVKPNATQE ELKKAYRKLA LKYHPDKNPN EGEKFKQISQ AYEVLSDAKK RELYDKGGEQ AIKEGGAGGG FGSPMDIFDM FFGGGGRMQR ERRGKNVVHQ LSVTLEDLYN GATRKLALQK NVICDKCEGR GGKKGAVECC PNCRGTGMQI RIHQIGPGMV QQIQSVCMEC QGHGERISPK DRCKSCNGRK IVREKKILEV HIDKGMKDGQ KITFHGEGDQ EPGLEPGDII IVLDQKDHAV FTRRGEDLFM CMDIQLVEAL CGFQKPISTL DNRTIVITSH PGQIVKHGDI KCVLNEGMPI YRRPYEKGRL IIEFKVNFPE NGFLSPDKLS LLEKLLPERK EVEETDEMDQ VELVDFDPNQ ERRRHYNGEA YEDDEHHPRG GVQC

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

37,045 Da

Sequence Positions

1-394, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

602837

3D Structure

ModBase 3D Structure for P31689

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of DNAJA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DNAJA1. It may not necessarily be applicable to this product.

NCBI GI #

4504511

NCBI GeneID

3301

NCBI Accession #

NP_001530.1

UniProt Primary Accession #

P31689

UniProt Secondary Accession #

Q5T7Q0; Q86TL9

UniProt Related Accession #

P31689

GenBank Nucleotide #

NM_001539.3

NCBI Official Full Name

dnaJ homolog subfamily A member 1 isoform 1

NCBI Official Synonym Full Names

DnaJ heat shock protein family (Hsp40) member A1

NCBI Official Symbol

DNAJA1

NCBI Official Synonym Symbols

DJ-2; DjA1; HDJ2; HSDJ; HSJ2; HSJ-2; HSPF4; NEDD7; hDJ-2

UniProt Protein Name

DnaJ homolog subfamily A member 1

UniProt Synonym Protein Names

DnaJ protein homolog 2; HSDJ; Heat shock 40 kDa protein 4; Heat shock protein J2; HSJ-2; Human DnaJ protein 2; hDj-2

Protein Family

DnaJ homolog subfamily

UniProt Gene Name

DNAJA1

UniProt Synonym Gene Names

DNAJ2; HDJ2; HSJ2; HSPF4; HSJ-2; hDj-2

NCBI Protein Information

dnaJ homolog subfamily A member 1

NCBI Summary for DNAJA1

This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015]

UniProt Comments for DNAJA1

Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202).

Research Articles on DNAJA1

1. that DNAJA1 controls the fate of misfolded stabilization of mutant p53

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DNAJA1 recombinant protein

Reference Product	PubMed Publications
HSPA8 recombinant protein	>10 publications with DNAJA1 and HSPA8
HSPA6 recombinant protein	>5 publications with DNAJA1 and HSPA6
HSP90AA1 recombinant protein	>1 publications with DNAJA1 and HSP90AA1
HSPA4 recombinant protein	>1 publications with DNAJA1 and HSPA4

Pathways associated with DNAJA1 recombinant protein

Products by Pathway	Pathway Diagram
Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies	Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram
Regulation Of Androgen Receptor Activity Pathway antibodies	Regulation Of Androgen Receptor Activity Pathway Diagram

Diseases associated with DNAJA1 recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>9 publications with DNAJA1 and Nervous System Diseases
Brain Diseases Antibodies	>7 publications with DNAJA1 and Brain Diseases
Cardiovascular Diseases Antibodies	>5 publications with DNAJA1 and Cardiovascular Diseases
Fibrosis Antibodies	>5 publications with DNAJA1 and Fibrosis
Disease Models, Animal Antibodies	>5 publications with DNAJA1 and Disease Models, Animal
Necrosis Antibodies	>3 publications with DNAJA1 and Necrosis
Cognition Disorders Antibodies	>2 publications with DNAJA1 and Cognition Disorders
Neoplasms, Experimental Antibodies	>2 publications with DNAJA1 and Neoplasms, Experimental
Atrophy Antibodies	>2 publications with DNAJA1 and Atrophy
Lung Diseases Antibodies	>2 publications with DNAJA1 and Lung Diseases

Organs/Tissues associated with DNAJA1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>17 publications with DNAJA1 and Blood
Brain Antibodies	>8 publications with DNAJA1 and Brain
Liver Antibodies	>7 publications with DNAJA1 and Liver
Muscle Antibodies	>5 publications with DNAJA1 and Muscle
Skin Antibodies	>5 publications with DNAJA1 and Skin
Nerve Antibodies	>4 publications with DNAJA1 and Nerve
Vascular Antibodies	>3 publications with DNAJA1 and Vascular
Kidney Antibodies	>3 publications with DNAJA1 and Kidney
Lung Antibodies	>3 publications with DNAJA1 and Lung
Testis Antibodies	>3 publications with DNAJA1 and Testis