Smoothened Homolog (SMO) Rat Recombinant Protein

SMO: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia. Belongs to the G-protein coupled receptor Fz/Smo family.

Protein type: GPCR, Fz/Smo family; Cell development/differentiation; Oncoprotein; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Cellular Component: Golgi apparatus; cell soma; intracellular membrane-bound organelle; dendrite; cytoplasm; postsynaptic density; integral to membrane; plasma membrane; caveola; cilium

Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; Wnt receptor activity; transmembrane receptor activity; patched binding; drug binding

Biological Process: heart morphogenesis; developmental growth; central nervous system development; ventral midline determination; negative regulation of epithelial cell differentiation; skeletal muscle fiber development; Wnt receptor signaling pathway through beta-catenin; anterior/posterior pattern formation; positive regulation of mesenchymal cell proliferation; positive regulation of smoothened signaling pathway; neural crest cell migration; activation of hh target transcription factor; positive regulation of neuroblast proliferation; forebrain morphogenesis; axon extension involved in axon guidance; cerebellar cortex morphogenesis; regulation of gene expression; midgut development; embryonic organ development; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; determination of left/right symmetry; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; central nervous system neuron differentiation; cell fate specification; negative regulation of transcription from RNA polymerase II promoter; thalamus development; response to organic substance; osteoblast proliferation; positive regulation of cell proliferation; response to wounding; facial nerve development; heart looping; vasculogenesis; dorsoventral neural tube patterning; ossification; smoothened signaling pathway; hair follicle morphogenesis; protein stabilization; in utero embryonic development; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; multicellular organism growth; smoothened signaling pathway in ventral spinal cord patterning; neurite regeneration; pattern specification process; negative regulation of hair follicle development; negative regulation of DNA binding; odontogenesis of dentine-containing teeth; osteoblast differentiation; G-protein coupled receptor protein signaling pathway; positive regulation of protein import into nucleus; dorsal/ventral pattern formation; gut development; homeostasis of number of cells within a tissue; myoblast migration; spermatogenesis; astrocyte activation; cell development