Synaptotagmin-1 (SYT1) Mouse Recombinant Protein

SYT1: an integral membrane protein of synaptic vesicles thought to serve as a Ca(2+) sensor in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse. Binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.

Protein type: Calcium-binding; Membrane protein, integral; Vesicle

Cellular Component: neuron projection; synaptic vesicle membrane; cell; integral to membrane; excitatory synapse; terminal button; intracellular organelle; secretory granule; SNARE complex; presynaptic membrane; synaptic vesicle; membrane; cytoplasm; plasma membrane; synapse; cytoplasmic vesicle; cell junction

Molecular Function: protein C-terminus binding; identical protein binding; clathrin binding; calcium-dependent phospholipid binding; metal ion binding; calcium ion binding; calcium-dependent protein binding; calmodulin binding; SNARE binding; protein binding; phosphatidylinositol-4,5-bisphosphate binding; syntaxin binding; low-density lipoprotein receptor binding; phosphatidylserine binding; syntaxin-1 binding; phospholipid binding

Biological Process: vesicle fusion; positive regulation of calcium ion-dependent exocytosis; synaptic vesicle exocytosis; regulation of synaptic transmission, glutamatergic; vesicle docking; neurotransmitter secretion; synaptic vesicle endocytosis; calcium ion-dependent exocytosis of neurotransmitter; positive regulation of vesicle fusion; detection of calcium ion; response to calcium ion; regulation of calcium ion-dependent exocytosis; positive regulation of synaptic transmission