Human CNGA1 Recombinant Protein – Cat# MBS7111482

Cgmp-Gated Cation Channel Alpha-1 (CNGA1) Human Recombinant Protein

Name: CNGA1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS7111482
Price: 965 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7111482

MBS7111482 is a recombinant protein targeting CNGA1. Also known as Recombinant Human cGMP-gated cation channel alpha-1 (CNGA1), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$965 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

cGMP-gated cation channel alpha-1 (CNGA1), Recombinant Protein

Full Product Name

Recombinant Human cGMP-gated cation channel alpha-1 (CNGA1), partial

Product Gene Name

CNGA1 recombinant protein

Sequence

AARAEFQARI DAIKQYMHFR NVSKDMEKRV IKWFDYLWTN KKTVDEKEVL KYLPDKLRAE IAINVHLDTL KKVRIFADCE AGLLVELVLK LQPQVYSPGD YICKKGDIGR EMYIIKEGKL AVVADDGVTQ FVVLSDGSYF GEISILNIKG SKAGNRRTAN IKSIGYSDLF CLSKDDLMEA LTEYPDAKTM LEEKGKQILM KDGLLDLNIA NAGSDPKDLE EKVTRMEGSV DLLQTRFARI LAEYESMQQK LKQRLTKVEK FLKPLIDTEF SSIEGPGAES GPIDST

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

86,900 Da

Sequence Positions

401-686aa; Partial

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

123825

3D Structure

ModBase 3D Structure for P29973

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CNGA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CNGA1. It may not necessarily be applicable to this product.

NCBI GI #

71143141

NCBI GeneID

1259

NCBI Accession #

NP_000078.2

UniProt Primary Accession #

P29973

UniProt Secondary Accession #

Q16279; Q16485; Q4W5E3; A8K7K6; J3KPZ2

UniProt Related Accession #

P29973

GenBank Nucleotide #

NM_000087.3

NCBI Official Full Name

cGMP-gated cation channel alpha-1 isoform 2

NCBI Official Synonym Full Names

cyclic nucleotide gated channel alpha 1

NCBI Official Symbol

CNGA1

NCBI Official Synonym Symbols

CNCG; CNG1; RP49; CNCG1; CNG-1; RCNC1; RCNCa; RCNCalpha

UniProt Protein Name

cGMP-gated cation channel alpha-1

UniProt Synonym Protein Names

Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated channel subunit alpha

Protein Family

cGMP-gated cation channel

UniProt Gene Name

CNGA1

UniProt Synonym Gene Names

CNCG; CNCG1; CNG channel alpha-1; CNG-1; CNG1

NCBI Protein Information

cGMP-gated cation channel alpha-1

NCBI Summary for CNGA1

The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

UniProt Comments for CNGA1

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.

Research Articles on CNGA1

1. Compound heterozygous mutations (NM000087, p.Y82X and p.L89fs) in exon 6 of CNGA1are pathogenic mutations in this Chinese family affected with autosomal recessive retinitis pigmentosa. Of which, p.Y82X is firstly reported in patient with autosomal recessive retinitis pigmentosa.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CNGA1 recombinant protein

Products by Pathway	Pathway Diagram
Phototransduction Pathway antibodies	Phototransduction Pathway Diagram
Phototransduction Pathway antibodies	Phototransduction Pathway Diagram
Visual Signal Transduction: Rods Pathway antibodies	Visual Signal Transduction: Rods Pathway Diagram

Diseases associated with CNGA1 recombinant protein

Disease Name	Pubmed Publications
Retinitis Pigmentosa Antibodies	>9 publications with CNGA1 and Retinitis Pigmentosa
Nervous System Diseases Antibodies	>1 publications with CNGA1 and Nervous System Diseases

Organs/Tissues associated with CNGA1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>21 publications with CNGA1 and Eye
Kidney Antibodies	>4 publications with CNGA1 and Kidney
Muscle Antibodies	>3 publications with CNGA1 and Muscle
Brain Antibodies	>2 publications with CNGA1 and Brain
Mouth Antibodies	>1 publications with CNGA1 and Mouth
Heart Antibodies	>1 publications with CNGA1 and Heart