Human IGF2 Recombinant Protein – Cat# MBS963767

Insulin-Like Growth Factor II (IGF2) Human Recombinant Protein

Name: IGF2 Recombinant Protein; Insulin-Like Growth Factor II; Human; MyBioSource
Brand: MyBioSource
SKU: MBS963767
Price: 670 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS963767

This gene encodes a member of the insulin family of polypeptide growth factors that is involved in development and growth. It is an imprinted gene and is expressed only from the paternally inherited allele. It is a candidate gene for eating disorders. There… More details

$670 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Insulin-like growth factor II (IGF2), Recombinant Protein

Full Product Name

Recombinant Human Insulin-like growth factor II (IGF2)

Product Gene Name

IGF2 recombinant protein

Sequence

AYRPSETLCG GELVDTLQFV CGDRGFYFSR PASRVSRRSR GIVEECCFRS CDLALLETYC ATPAKSE

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

26,331 Da

Sequence Positions

25-91, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

147470

3D Structure

ModBase 3D Structure for P01344

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of IGF2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IGF2 purchase

MBS963767 is a recombinant protein targeting IGF2. Also known as Recombinant Human Insulin-like growth factor II (IGF2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for IGF2. It may not necessarily be applicable to this product.

NCBI GI #

4504609

NCBI GeneID

3481

NCBI Accession #

NP_000603.1

UniProt Primary Accession #

P01344

UniProt Secondary Accession #

P78449; Q14299; Q1WM26; Q9UC68; Q9UC69; B3KX48; B7WP08; C9JAF2; E3UN45

UniProt Related Accession #

P01344

GenBank Nucleotide #

NM_000612.5

NCBI Official Full Name

insulin-like growth factor II isoform 1 preproprotein

NCBI Official Synonym Full Names

insulin like growth factor 2

NCBI Official Symbol

IGF2

NCBI Official Synonym Symbols

GRDF; IGF-II; PP9974; C11orf43

UniProt Protein Name

Insulin-like growth factor II

UniProt Synonym Protein Names

Somatomedin-A; T3M-11-derived growth factor

Protein Family

Insulin-like growth factor

UniProt Gene Name

IGF2

UniProt Synonym Gene Names

IGF-II

NCBI Protein Information

insulin-like growth factor II

NCBI Summary for IGF2

This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

UniProt Comments for IGF2

The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable).

Research Articles on IGF2

1. IGF-II-mediated loss of E-cadherin is central in developing hepatomegaly in mice and abnormal cell growth in the hepatoma cell line

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IGF2 recombinant protein

Reference Product	PubMed Publications
IGF2R recombinant protein	>183 publications with IGF2 and IGF2R
IGF1R recombinant protein	>140 publications with IGF2 and IGF1R
IGFBP3 recombinant protein	>63 publications with IGF2 and IGFBP3
IGFBP2 recombinant protein	>39 publications with IGF2 and IGFBP2
IGFBP1 recombinant protein	>25 publications with IGF2 and IGFBP1
IGFBP4 recombinant protein	>16 publications with IGF2 and IGFBP4
IGFBP5 recombinant protein	>16 publications with IGF2 and IGFBP5
IGF2BP2 recombinant protein	>11 publications with IGF2 and IGF2BP2
IGFBP6 recombinant protein	>9 publications with IGF2 and IGFBP6
IGF2BP1 recombinant protein	>7 publications with IGF2 and IGF2BP1

Pathways associated with IGF2 recombinant protein

Products by Pathway	Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Cardiac Progenitor Differentiation Pathway antibodies	Cardiac Progenitor Differentiation Pathway Diagram
Endochondral Ossification Pathway antibodies	Endochondral Ossification Pathway Diagram
Hedgehog Signaling Pathway antibodies	Hedgehog Signaling Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
IGF1R Signaling Cascade Pathway antibodies	IGF1R Signaling Cascade Pathway Diagram
IRS-related Events Triggered By IGF1R Pathway antibodies	IRS-related Events Triggered By IGF1R Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Platelet Activation, Signaling And Aggregation Pathway antibodies	Platelet Activation, Signaling And Aggregation Pathway Diagram
Platelet Degranulation Pathway antibodies	Platelet Degranulation Pathway Diagram

Diseases associated with IGF2 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>634 publications with IGF2 and Neoplasms
Wilms Tumor Antibodies	>141 publications with IGF2 and Wilms Tumor
Beckwith-Wiedemann Syndrome Antibodies	>140 publications with IGF2 and Beckwith-Wiedemann Syndrome
Growth Disorders Antibodies	>117 publications with IGF2 and Growth Disorders
Kidney Diseases Antibodies	>113 publications with IGF2 and Kidney Diseases
Colorectal Neoplasms Antibodies	>99 publications with IGF2 and Colorectal Neoplasms
Liver Neoplasms Antibodies	>99 publications with IGF2 and Liver Neoplasms
Liver Diseases Antibodies	>97 publications with IGF2 and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>62 publications with IGF2 and Carcinoma, Hepatocellular
Breast Neoplasms Antibodies	>61 publications with IGF2 and Breast Neoplasms

Organs/Tissues associated with IGF2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>256 publications with IGF2 and Muscle
Blood Antibodies	>244 publications with IGF2 and Blood
Liver Antibodies	>210 publications with IGF2 and Liver
Embryonic Tissue Antibodies	>207 publications with IGF2 and Embryonic Tissue
Placenta Antibodies	>147 publications with IGF2 and Placenta
Kidney Antibodies	>140 publications with IGF2 and Kidney
Bone Antibodies	>121 publications with IGF2 and Bone
Brain Antibodies	>109 publications with IGF2 and Brain
Connective Tissue Antibodies	>80 publications with IGF2 and Connective Tissue
Lung Antibodies	>61 publications with IGF2 and Lung