Human CLDN8 Recombinant Protein – Cat# MBS963858

Claudin-8 (CLDN8) Human Recombinant Protein

Name: CLDN8 Recombinant Protein; Claudin-8; Human; MyBioSource
Brand: MyBioSource
SKU: MBS963858
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS963858

MBS963858 is a recombinant protein targeting CLDN8. Also known as Recombinant Human Claudin-8 (CLDN8). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Claudin-8 (CLDN8), Recombinant Protein

Full Product Name

Recombinant Human Claudin-8 (CLDN8)

Product Gene Name

CLDN8 recombinant protein

Product Synonym Gene Name

CLDN8; UNQ779/PRO1573

Product Synonym Names

Recombinant Claudin-8 (CLDN8); Claudin-8

Sequence

MATHALEIAG LFLGGVGMVG TVAVTVMPQW RVSAFIENNI VVFENFWEGL WMNCVRQANI RMQCKIYDSL LALSPDLQAA RGLMCAASVM SFLAFMMAIL GMKCTRCTGD NEKVKAHILL TAGIIFIITG MVVLIPVSWV ANAIIRDFYN SIVNVAQKRE LGEALYLGWT TALVLIVGGA LFCCVFCCNE KSSSYRYSIP SHRTTQKSYH TGKKSPSVYS RSQYV

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

24,845 Da

Sequence Positions

1-225

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 21; NC_000021.8 (31586324..31588469, complement). Location: 21q22.11

OMIM

611231

3D Structure

ModBase 3D Structure for P56748

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CLDN8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CLDN8. It may not necessarily be applicable to this product.

NCBI GI #

40788011

NCBI GeneID

9073

NCBI Accession #

NP_955360.1

UniProt Primary Accession #

P56748

UniProt Secondary Accession #

Q53EX7; D3DSE3

UniProt Related Accession #

P56748

GenBank Nucleotide #

NM_199328.2

NCBI Official Full Name

claudin-8

NCBI Official Synonym Full Names

claudin 8

NCBI Official Symbol

CLDN8

UniProt Protein Name

Claudin-8

Protein Family

Claudin

UniProt Gene Name

CLDN8

UniProt Entry Name

CLD8_HUMAN

NCBI Protein Information

claudin-8

NCBI Summary for CLDN8

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010]

UniProt Comments for CLDN8

Claudin-8: Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family.

Protein type: Endoplasmic reticulum; Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: tight junction; basolateral plasma membrane; endoplasmic reticulum; plasma membrane; integral to membrane

Molecular Function: identical protein binding; structural molecule activity

Biological Process: calcium-independent cell-cell adhesion

Research Articles on CLDN8

1. the combination of CK7, S100A1 and claudin 8 immunohistochemistry can be useful for classifying tumours of overlapping histology as chromophobe renal cell carcinoma or renal oncocytomas.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CLDN8 recombinant protein

Reference Product	PubMed Publications
TJP1 recombinant protein	>1 publications with CLDN8 and TJP1

Pathways associated with CLDN8 recombinant protein

Products by Pathway	Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Junction Organization Pathway antibodies	Cell Junction Organization Pathway Diagram
Cell-Cell Communication Pathway antibodies	Cell-Cell Communication Pathway Diagram
Cell-cell Junction Organization Pathway antibodies	Cell-cell Junction Organization Pathway Diagram
Hepatitis C Pathway antibodies	Hepatitis C Pathway Diagram
Hepatitis C Pathway antibodies	Hepatitis C Pathway Diagram
Leukocyte Transendothelial Migration Pathway antibodies	Leukocyte Transendothelial Migration Pathway Diagram
Leukocyte Transendothelial Migration Pathway antibodies	Leukocyte Transendothelial Migration Pathway Diagram
Tight Junction Pathway antibodies	Tight Junction Pathway Diagram

Diseases associated with CLDN8 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>3 publications with CLDN8 and Neoplasms
Breast Neoplasms Antibodies	>1 publications with CLDN8 and Breast Neoplasms
Skin Diseases Antibodies	>1 publications with CLDN8 and Skin Diseases
Asthma Antibodies	>1 publications with CLDN8 and Asthma
Arthritis, Rheumatoid Antibodies	>1 publications with CLDN8 and Arthritis, Rheumatoid
Inflammation Antibodies	>1 publications with CLDN8 and Inflammation

Organs/Tissues associated with CLDN8 recombinant protein

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>2 publications with CLDN8 and Skin
Mammary Gland Antibodies	>1 publications with CLDN8 and Mammary Gland