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Beta-1 Adrenergic Receptor (ADRB1) Dog Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS964118

MBS964118 is a recombinant protein targeting ADRB1. Also known as Recombinant Dog Beta-1 adrenergic receptor (ADRB1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Beta-1 adrenergic receptor (ADRB1), Recombinant Protein
Full Product Name
Recombinant Dog Beta-1 adrenergic receptor (ADRB1)
Product Gene Name
ADRB1 recombinant protein
Product Synonym Gene Name
ADRB1
Product Synonym Names
Recombinant Beta-1 adrenergic receptor (ADRB1); Beta-1 adrenergic receptor; Beta-1 adrenoreceptor; Beta-1 adrenoceptor
Sequence
MGAGALALGA SEPCNLSSAA PLPDGAATAA RLLVPASPSA SPLAPTSEGP APLSQQWTAG IGLLMALIVL LIVAGNVLVI AAIAKTPRLQ TLTNLFIMSL ASADLVMGLL VVPFGATIVM RGRWEYGSFL CELWTSVDVL CVTASIETLC VIALDRYLAI TAPFRYQSLL TRARARALVC TVWAISALVS FLPILMHWWR AGGDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM AFVYLRVFRE AQKQVKKIDS CERRFLGGPA RPPAPPPAPA PAPPPAPGSP RPAAAAPLAN GRVGRRRPSR LVALREQKAL KTLGIIMGVF TLCWLPFFLA NVVKAFHRDL VPDRLFVFFN WLGYANSAFN PIIYCRSPDF RRAFQRLLCC ARRAARGSHG AAGDPPRARP PPSPGAASDD DDDDEDDAGA GAGAAPPARL LEPWAGCNGG AAADSDSSLD GAGSPAGASE SRV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
50,061 Da
Sequence Positions
1-473
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 28; NC_006610.3 (24908224..24909684). Location: chromosome: 28
3D Structure
ModBase 3D Structure for P79148
Species
Canis familiaris (Dog) (Canis lupus familiaris)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ADRB1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ADRB1. It may not necessarily be applicable to this product.

NCBI GI #
56790271
NCBI GeneID
493972
NCBI Accession #
NP_001008713.1
UniProt Primary Accession #
P79148
UniProt Related Accession #
P79148
GenBank Nucleotide #
NM_001008713.1
NCBI Official Full Name
beta-1 adrenergic receptor
NCBI Official Symbol
ADRB1
UniProt Protein Name
Beta-1 adrenergic receptor
UniProt Synonym Protein Names
Beta-1 adrenoreceptor
Protein Family
Beta-1 adrenergic receptor
UniProt Gene Name
ADRB1
UniProt Synonym Gene Names
Beta-1 adrenoceptor
UniProt Entry Name
ADRB1_CANFA
NCBI Protein Information
beta-1 adrenergic receptor; beta-1 adrenoceptor; beta-1 adrenoreceptor; adrenergic, beta-1-, receptor

UniProt Comments for ADRB1

Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.

Subunit structure: Interacts with GOPC, MAGI3 and DLG4

By similarity.

Subcellular location: Cell membrane; Multi-pass membrane protein

By similarity. Note: Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression

By similarity.

Domain: The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor

By similarity.

Post-translational modification: Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase

By similarity.

Sequence similarities: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.
Show more

Research Articles on ADRB1

1. cardiac pacemaker improves rest and beta-adrenergic-stimulated myocyte function and calcium handling, upregulating beta(1) receptors and adenylate cyclase activity and suppressing G(i)-coupled signaling associated with novel RGS upregulation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ADRB1 recombinant protein

 Products by Pathway  Pathway Diagram
 Adrenoceptors Pathway antibodies  Adrenoceptors Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram

Diseases associated with ADRB1 recombinant protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1061 publications with ADRB1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >897 publications with ADRB1 and Heart Diseases
 Heart Failure Antibodies  >540 publications with ADRB1 and Heart Failure
 Hypertension Antibodies  >315 publications with ADRB1 and Hypertension
 Cardiomegaly Antibodies  >235 publications with ADRB1 and Cardiomegaly
 Cardiomyopathies Antibodies  >220 publications with ADRB1 and Cardiomyopathies
 Myocardial Ischemia Antibodies  >207 publications with ADRB1 and Myocardial Ischemia
 Cardiomyopathy, Dilated Antibodies  >198 publications with ADRB1 and Cardiomyopathy, Dilated
 Arrhythmias, Cardiac Antibodies  >168 publications with ADRB1 and Arrhythmias, Cardiac
 Tachycardia Antibodies  >156 publications with ADRB1 and Tachycardia

Organs/Tissues associated with ADRB1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >90 publications with ADRB1 and Mixed
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