Human PIGP Recombinant Protein – Cat# MBS964259

Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit P (PIGP) Human Recombinant Protein

Name: PIGP Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS964259
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS964259

MBS964259 is a recombinant protein targeting PIGP. Also known as Recombinant Human Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (PIGP). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (PIGP), Recombinant Protein

Full Product Name

Recombinant Human Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (PIGP)

Product Gene Name

PIGP recombinant protein

Product Synonym Gene Name

PIGP; DCRC, DSCR5, DSCRC; NPD010

Product Synonym Names

Recombinant Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (PIGP); Phosphatidylinositol N-acetylglucosaminyltransferase subunit P EC= 2.4.1.198; Down syndrome critical region protein 5 Down syndrome critical region protein C Phosphatidylin

Sequence

MVPRSTSLTL IVFLFHRLSK APGKMVENSP SPLPERAIYG FVLFLSSQFG FILYLVWAFI PESWLNSLGL TYWPQKYWAV ALPVYLLIAI VIGYVLLFGI NMMSTSPLDS IHTITDNYAK NQQQKKYQEE AIPALRDISI SEVNQMFFLA AKELYTKN

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

18,059 Da

Sequence Positions

1-158

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 21; NC_000021.8 (38437664..38445458, complement). Location: 21q22.2

OMIM

605938

3D Structure

ModBase 3D Structure for P57054

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PIGP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PIGP. It may not necessarily be applicable to this product.

NCBI GI #

24497597

NCBI GeneID

51227

NCBI Accession #

NP_710148.1

UniProt Primary Accession #

P57054

UniProt Secondary Accession #

Q53Y28; Q96KI1; Q9NZA6; B2RB18; B2RE99; B5BU92; D3DSG7; J3KR75

UniProt Related Accession #

P57054

GenBank Nucleotide #

NM_153681.2

NCBI Official Full Name

phosphatidylinositol N-acetylglucosaminyltransferase subunit P isoform 1

NCBI Official Synonym Full Names

phosphatidylinositol glycan anchor biosynthesis, class P

NCBI Official Symbol

PIGP

NCBI Official Synonym Symbols

DCRC; DSRC; DSCR5; DCRC-S

UniProt Protein Name

Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

UniProt Synonym Protein Names

Down syndrome critical region protein 5; Down syndrome critical region protein C; Phosphatidylinositol-glycan biosynthesis class P protein

UniProt Gene Name

PIGP

UniProt Synonym Gene Names

DCRC; DSCR5; DSCRC; PIG-P

UniProt Entry Name

PIGP_HUMAN

NCBI Protein Information

phosphatidylinositol N-acetylglucosaminyltransferase subunit P; PIG-P; Down syndrome critical region gene 5; phosphatidylinositol glycan, class P; Down syndrome critical region protein 5; Down syndrome critical region protein C; phosphatidylinositol-glycan biosynthesis class P protein; phosphatidylinositol-n-acetylglucosaminyltranferase subunit

NCBI Summary for PIGP

This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

UniProt Comments for PIGP

PIGP: Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Belongs to the PIGP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 2.4.1.198; Transferase; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 21q22.2

Cellular Component: endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; integral to membrane

Molecular Function: phosphatidylinositol N-acetylglucosaminyltransferase activity

Biological Process: cellular protein metabolic process; preassembly of GPI anchor in ER membrane; C-terminal protein lipidation; post-translational protein modification

Research Articles on PIGP

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PIGP recombinant protein

Products by Pathway	Pathway Diagram
Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway antibodies	Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway Diagram
Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway antibodies	Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway antibodies	Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram
Synthesis Of Glycosylphosphatidylinositol (GPI) Pathway antibodies	Synthesis Of Glycosylphosphatidylinositol (GPI) Pathway Diagram

Diseases associated with PIGP recombinant protein

Disease Name	Pubmed Publications
Neurologic Manifestations Antibodies	>5 publications with PIGP and Neurologic Manifestations
Stomach Diseases Antibodies	>2 publications with PIGP and Stomach Diseases
Gastrointestinal Diseases Antibodies	>2 publications with PIGP and Gastrointestinal Diseases
Nausea Antibodies	>1 publications with PIGP and Nausea
Vomiting Antibodies	>1 publications with PIGP and Vomiting
Anemia Antibodies	>1 publications with PIGP and Anemia
Anemia, Hemolytic Antibodies	>1 publications with PIGP and Anemia, Hemolytic

Organs/Tissues associated with PIGP recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>1 publications with PIGP and Brain