Human MMP15 Recombinant Protein – Cat# MBS964388

Matrix Metalloproteinase-15 (MMP15) Human Recombinant Protein

Name: MMP15 Recombinant Protein; Matrix Metalloproteinase-15; Human; MyBioSource
Brand: MyBioSource
SKU: MBS964388
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS964388

MBS964388 is a recombinant protein targeting MMP15. Also known as Recombinant Human Matrix metalloproteinase-15 (MMP15). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Matrix metalloproteinase-15 (MMP15), Recombinant Protein

Full Product Name

Recombinant Human Matrix metalloproteinase-15 (MMP15)

Product Gene Name

MMP15 recombinant protein

Product Synonym Names

Matrix metalloproteinase-15; MMP-15; EC=3.4.24.-; Membrane-type matrix metalloproteinase 2; MT-MMP 2; MTMMP2; Membrane-type-2 matrix metalloproteinase; MT2-MMP; MT2MMP; SMCP-2

Sequence

YALTGRKWN NHHLTFSIQN YTEKLGWYHS MEAVRRAFRV WEQATPLVFQ EVPYEDIRLR RQKEADIMVL FASGFHGDSS PFDGTGGFLA HAYFPGPGLG GDTHFDADEP WTFSSTDLHG NNLFLVAVHE LGHALGLEHS SNPNAIMAPF YQWKDVDNFK LPEDDLRGIQ QLYGTPDGQP QPTQPLPTVT PRRPGRPDHR PPRPPQPPPP GGKPERPPKP GPPVQPRATE RPDQYGPNIC DGDFDTVAML RGEMFVFKGR WFWRVRHNRV LDNYPMPIGH FWRGLPGDIS AAYERQDGRF VFFKGDRYWL FREANLEPGY PQPLTSYGLG IPYDRIDTAI WWEPTGHTFF FQEDRYWRFN EETQRGDPGY PKPISVWQGI PASPKGAFLS NDAAYTYFYK GTKYWKFDNE RLRMEPGYPK SILRDFMGCQ EHVEPGPRWP DVARPPFNPH GGAEPGADSA EGDVGDGDGD FGAGVNKDGG SRVVVQMEEV ARTVN

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

75,807 Da

Sequence Positions

132-625

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

602261

3D Structure

ModBase 3D Structure for P51511

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MMP15 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP15. It may not necessarily be applicable to this product.

NCBI GI #

4505211

NCBI GeneID

4324

NCBI Accession #

NP_002419.1

UniProt Primary Accession #

P51511

UniProt Secondary Accession #

Q14111; A0A2U6

UniProt Related Accession #

P51511

GenBank Nucleotide #

NM_002428.2

NCBI Official Full Name

matrix metalloproteinase-15 preproprotein

NCBI Official Synonym Full Names

matrix metallopeptidase 15 (membrane-inserted)

NCBI Official Symbol

MMP15

NCBI Official Synonym Symbols

MTMMP2; SMCP-2; MT2-MMP

UniProt Protein Name

Matrix metalloproteinase-15

UniProt Synonym Protein Names

Membrane-type matrix metalloproteinase 2; MT-MMP 2; MTMMP2; Membrane-type-2 matrix metalloproteinase; MT2-MMP; MT2MMP; SMCP-2

Protein Family

Matrix metalloproteinase

UniProt Gene Name

MMP15

UniProt Synonym Gene Names

MMP-15; MT-MMP 2; MTMMP2; MT2-MMP; MT2MMP

UniProt Entry Name

MMP15_HUMAN

NCBI Protein Information

matrix metalloproteinase-15; MMP-15; MT2MMP; MT-MMP 2; membrane-type matrix metalloproteinase 2; membrane-type-2 matrix metalloproteinase; matrix metalloproteinase 15 (membrane-inserted)

NCBI Summary for MMP15

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. [provided by RefSeq, Jul 2008]

UniProt Comments for MMP15

MMP15: Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. Belongs to the peptidase M10A family.

Protein type: Protease; Membrane protein, integral; EC 3.4.24.-

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: extracellular matrix; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; zinc ion binding; metalloendopeptidase activity; enzyme activator activity; calcium ion binding

Biological Process: positive regulation of catalytic activity; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; protein modification process; proteolysis; response to estradiol stimulus

Research Articles on MMP15

1. HLA-G expression involved in tumor invasiveness or metastasis may rely on the NK cytotoxicity inhibition and induction of MMP-15 expression in ovarian cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MMP15 recombinant protein

Reference Product	PubMed Publications
LRP1 recombinant protein	>1 publications with MMP15 and LRP1

Pathways associated with MMP15 recombinant protein

Products by Pathway	Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Degradation Of Collagen Pathway antibodies	Degradation Of Collagen Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Matrix Metalloproteinases Pathway antibodies	Matrix Metalloproteinases Pathway Diagram

Diseases associated with MMP15 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>36 publications with MMP15 and Neoplasms
Adenocarcinoma Antibodies	>8 publications with MMP15 and Adenocarcinoma
Breast Neoplasms Antibodies	>6 publications with MMP15 and Breast Neoplasms
Carcinoma, Squamous Cell Antibodies	>5 publications with MMP15 and Carcinoma, Squamous Cell
Cell Transformation, Neoplastic Antibodies	>4 publications with MMP15 and Cell Transformation, Neoplastic
Nervous System Diseases Antibodies	>2 publications with MMP15 and Nervous System Diseases
Disease Models, Animal Antibodies	>2 publications with MMP15 and Disease Models, Animal
Fibrosis Antibodies	>2 publications with MMP15 and Fibrosis
Inflammation Antibodies	>2 publications with MMP15 and Inflammation
Skin Neoplasms Antibodies	>2 publications with MMP15 and Skin Neoplasms

Organs/Tissues associated with MMP15 recombinant protein

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>8 publications with MMP15 and Vascular
Skin Antibodies	>7 publications with MMP15 and Skin
Blood Antibodies	>7 publications with MMP15 and Blood
Lung Antibodies	>7 publications with MMP15 and Lung
Placenta Antibodies	>6 publications with MMP15 and Placenta
Embryonic Tissue Antibodies	>6 publications with MMP15 and Embryonic Tissue
Brain Antibodies	>5 publications with MMP15 and Brain
Bone Antibodies	>4 publications with MMP15 and Bone
Muscle Antibodies	>3 publications with MMP15 and Muscle
Connective Tissue Antibodies	>3 publications with MMP15 and Connective Tissue