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RNA Polymerase-Associated Protein RTF1 Homolog (RTF1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS964620

MBS964620 is a recombinant protein targeting Rtf1. Also known as Recombinant Mouse RNA polymerase-associated protein RTF1 homolog (Rtf1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1560 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RNA polymerase-associated protein RTF1 homolog (Rtf1), Recombinant Protein
Full Product Name
Recombinant Mouse RNA polymerase-associated protein RTF1 homolog (Rtf1)
Product Gene Name
Rtf1 recombinant protein
Sequence
MRGRLCVGRA AAVAAAVAAA AVAVPLAGGQ EGSQGGVRRG SRGTTMVKKR KGRVVIDSDT EDSGSDENLD QELLSLAKRK RSDSEEKEPP VSQPAASSDS ETSDSDDEWT FGSNKNKKKG KTRKVEKKGA MKKQANKAAS SGSSDRDSSA ESSAPEEGEV SDSESSSSSS SSDSDSSSED EEFHDGYGED LMGDEEDRAR LEQMTEKERE QELFNRIEKR EVLKRRFEIK KKLKTAKKKE KKEKKKKQEE EQEKKKLTQI QESQVTSHNK ERRSKRDEKL DKKSQAMEEL KAEREKRKNR TAELLAKKQP LKTSEVYSDD EEEEDDDKSS EKSDRSSRTS SSDEEEEKEE IPPKSQPVSL PEELNRVRLS RHKLERWCHM PFFAKTVTGC FVRIGIGNHN SKPVYRVAEI TGVVETAKVY QLGGTRTNKG LQLRHGNDQR VFRLEFVSNQ EFTESEFMKW KEAMFSAGMQ LPTLDEINKK ELSIKEALNY KFNDQDIEEI VKEKERFRKA PPNYAMKKTQ LLKEKAMAED LGDQDKAKQI QDQLNELEER AEALDRQRTK NISAISYINQ RNREWNIVES EKALVAESHN MRNQQMDPFT RRQCKPTIVS NSRDPAVQAA ILAQLNAKYG SGVLPDAPKE MSKGQGKDKD LNSKTASDLS EDLFKVHDFD VKIDLQVPSS ESKALAITSK APPAKDGAPR RSLNLEDYKK RRGLI
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
80,797 Da
Sequence Positions
1-715, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for A2AQ19
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Rtf1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Rtf1. It may not necessarily be applicable to this product.

NCBI GI #
195976788
NCBI GeneID
76246
NCBI Accession #
NP_084388.2
UniProt Primary Accession #
A2AQ19
UniProt Secondary Accession #
Q08EC5
UniProt Related Accession #
A2AQ19
GenBank Nucleotide #
NM_030112.2
NCBI Official Full Name
RNA polymerase-associated protein RTF1 homolog
NCBI Official Synonym Full Names
RTF1, Paf1/RNA polymerase II complex component
NCBI Official Symbol
Rtf1
NCBI Official Synonym Symbols
Gtl7; cbp82; AI853581; AU043144; AW553985; 2900005O08Rik; 6530416A09Rik
UniProt Protein Name
RNA polymerase-associated protein RTF1 homolog
Protein Family
Replication termination factor
UniProt Gene Name
Rtf1
NCBI Protein Information
RNA polymerase-associated protein RTF1 homolog

UniProt Comments for Rtf1

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Binds single-stranded DNA (). Required for maximal induction of heat-shock genes. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of a SET1 complex.
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Research Articles on Rtf1

1. Potential role of Rtf1 Plus single stranded DNA binding during transcription elongation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with Rtf1 recombinant protein

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >1 publications with Rtf1 and Kidney Diseases
 Adenocarcinoma Antibodies  >1 publications with Rtf1 and Adenocarcinoma
 Colonic Neoplasms Antibodies  >1 publications with Rtf1 and Colonic Neoplasms
 Hepatitis Antibodies  >1 publications with Rtf1 and Hepatitis
 Liver Cirrhosis Antibodies  >1 publications with Rtf1 and Liver Cirrhosis
 Carcinoma Antibodies  >1 publications with Rtf1 and Carcinoma
 Inflammation Antibodies  >1 publications with Rtf1 and Inflammation
 Liver Diseases Antibodies  >1 publications with Rtf1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with Rtf1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with Rtf1 and Liver Neoplasms

Organs/Tissues associated with Rtf1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >2 publications with Rtf1 and Heart
 Kidney Antibodies  >1 publications with Rtf1 and Kidney
 Brain Antibodies  >1 publications with Rtf1 and Brain
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