Sex Hormone-Binding Globulin (SHBG) Human Recombinant Protein

MBS964742 is a recombinant protein targeting SHBG. Also known as Recombinant Human Sex hormone-binding globulin. Host: E. coli.

Characterization of the human sex hormone binding globulin (SHBG) gene and demonstration of two transcripts in both liver and testis.Gershagen S., Lundwall A., Fernlund P.Nucleic Acids Res. 17:9245-9258(1989) The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs.Hammond G.L., Underhill D.A., Rykse H.M., Smith C.L.Mol. Endocrinol. 3:1869-1876(1989) PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.Jin P., Fu G.K., Wilson A.D., Yang J., Chien D., Hawkins P.R., Au-Young J., Stuve L.L.Genomics 83:566-571(2004) DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.Nature 440:1045-1049(2006) The cDNA-deduced primary structure of human sex hormone-binding globulin and location of its steroid-binding domain.Hammond G.L., Underhill D.A., Smith C.L., Goping I.S., Harley M.J., Musto N.A., Cheng C.Y., Bardin C.W.FEBS Lett. 215:100-104(1987) Human sex hormone-binding globulin gene transcript expression in liver, prostate, breast, testis, and brain- multiple promoters and complex alternative splicing.Kahn S.M., Nakhla A.M., Hryb D.J., Rosner W., Romas N.A. A cDNA coding for human sex hormone binding globulin. Homology to vitamin K-dependent protein S.Gershagen S., Fernlund P., Lundwall A.FEBS Lett. 220:129-135(1987) Characterization of a cDNA coding for sex steroid-binding protein of human plasma.Que B.G., Petra P.H.FEBS Lett. 219:405-409(1987) Physicochemical characteristics of human sex hormone binding globulin evidence for two identical subunits.Hammond G.L., Robinson P.A., Sugino H., Ward D.N., Finne J.J. Steroid Biochem. 24:815-824(1986) Amino acid sequence of the sex steroid binding protein of human blood plasma.Walsh K.A., Titani K., Takio K., Kumar S., Hayes R., Petra P.H.Biochemistry 25:7584-7590(1986) Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.J. Proteome Res. 4:2070-2080(2005) Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.J. Proteome Res. 8:651-661(2009) Molecular analyses of a human sex hormone-binding globulin variant evidence for an additional carbohydrate chain.Power S.G.A., Bocchinfuso W.P., Pallesen M., Warmels-Rodenhiser S., Van Baelen H., Hammond G.L.J. Clin. Endocrinol. Metab. 75:1066-1070(1992) Crystal structure of human sex hormone-binding globulin steroid transport by a laminin G-like domain.Grishkovskaya I., Avvakumov G.V., Sklenar G., Dales D., Hammond G.L., Muller Y.A.EMBO J. 19:504-512(2000) Steroid ligands bind human sex hormone-binding globulin in specific orientations and produce distinct changes in protein conformation.Grishkovskaya I., Avvakumov G.V., Hammond G.L., Catalano M.G., Muller Y.A.J. Biol. Chem. 277:32086-32093(2002) Molecular characterization of a genetic variant of the steroid hormone-binding globulin gene in heterozygous subjects.Hardy D.O., Carino C., Catterall J.F., Larrea F.J. Clin. Endocrinol. Metab. 80:1253-1256(1995) Characterization of single-nucleotide polymorphisms in coding regions of human genes.Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.Nat. Genet. 22:231-238(1999) ErratumCargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.Nat. Genet. 23:373-373(1999)

Small volumes of SHBG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.