Chicken ISL1 Recombinant Protein – Cat# MBS965183

Insulin Gene Enhancer Protein ISL-1 (ISL1) Chicken Recombinant Protein

Name: ISL1 Recombinant Protein; Chicken; MyBioSource
Brand: MyBioSource
SKU: MBS965183
Price: 1065 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS965183

This gene encodes a member of the LIMhomeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is… More details

$1065 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Insulin gene enhancer protein ISL-1 (ISL1), Recombinant Protein

Full Product Name

Recombinant Chicken Insulin gene enhancer protein ISL-1 (ISL1)

Product Gene Name

ISL1 recombinant protein

Sequence

MGDMGDPPKK KRLISLCVGC GNQIHDQYIL RVSPDLEWHA ACLKCAECNQ YLDETCTCFV RDGKTYCKRD YIRLYGIKCA KCSIGFSKND FVMRARAKVY HIECFRCVAC SRQLIPGDEF ALREDGLFCR ADHDVVERAS LGAGDPLSPL HPARPLQMAA EPISARQPAL RPHVHKQPEK TTRVRTVLNE KQLHTLRTCY AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKRS IMMKQLQQQQ PNDKTNIQGM TGTPMVAASP ERHDGGLQAN PVEVQSYQPP WKVLSDFALQ SDIDQPAFQQ LVNFSEGGPG SNSTGSEVAS MSSQLPDTPN SMVASPIEA

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

39,034 Da

Sequence Positions

1-349, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P50211

Species

Chicken

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ISL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ISL1 purchase

MBS965183 is a recombinant protein targeting ISL1. Also known as Recombinant Chicken Insulin gene enhancer protein ISL-1 (ISL1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for ISL1. It may not necessarily be applicable to this product.

NCBI GI #

45382271

NCBI GeneID

396383

NCBI Accession #

NP_990745.1

UniProt Primary Accession #

P50211

UniProt Related Accession #

P50211

GenBank Nucleotide #

NM_205414.1

NCBI Official Full Name

insulin gene enhancer protein ISL-1

NCBI Official Synonym Full Names

ISL LIM homeobox 1

NCBI Official Symbol

ISL1

NCBI Official Synonym Symbols

ISL-1; ISLET-1

UniProt Protein Name

Insulin gene enhancer protein ISL-1

Protein Family

Insulin gene enhancer protein

UniProt Gene Name

ISL1

UniProt Synonym Gene Names

ISL-1; Islet-1

NCBI Protein Information

insulin gene enhancer protein ISL-1

UniProt Comments for ISL1

Acts as a transcriptional regulator (PubMed:7528105). Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways (PubMed:7528105). Acts in conjunction with LHX1, LHX3 and ISL2 (PubMed:7528105). Binds to insulin gene enhancer sequences (). Essential for heart development ().

Research Articles on ISL1

1. Data indicate that myocardial markers ISL1, TNNI2 and NKX2-5 and HCN4 were studied in sequential stages of chick embryo development.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with ISL1 recombinant protein

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>35 publications with ISL1 and Heart Diseases
Cardiovascular Diseases Antibodies	>34 publications with ISL1 and Cardiovascular Diseases
Congenital Abnormalities Antibodies	>29 publications with ISL1 and Congenital Abnormalities
Heart Defects, Congenital Antibodies	>23 publications with ISL1 and Heart Defects, Congenital
Cardiovascular Abnormalities Antibodies	>21 publications with ISL1 and Cardiovascular Abnormalities
Nervous System Diseases Antibodies	>10 publications with ISL1 and Nervous System Diseases
Lung Neoplasms Antibodies	>5 publications with ISL1 and Lung Neoplasms
Fibrosis Antibodies	>4 publications with ISL1 and Fibrosis
Neoplasm Metastasis Antibodies	>4 publications with ISL1 and Neoplasm Metastasis
Breast Neoplasms Antibodies	>4 publications with ISL1 and Breast Neoplasms

Organs/Tissues associated with ISL1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Head Antibodies	>5 publications with ISL1 and Head
Uncharacterized Tissue Antibodies	>1 publications with ISL1 and Uncharacterized Tissue
Utricle Antibodies	>1 publications with ISL1 and Utricle