Lutropin-Choriogonadotropic Hormone Receptor (LHCGR) Rat Recombinant Protein

LHR: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in LHCGR are a cause of familial male precocious puberty (FMPP); also known as testotoxicosis. In FMPP the receptor is constitutively activated. Defects in LHCGR are the cause of luteinizing hormone resistance (LHR); also known as Leydig cell hypoplasia in males. LHR is an autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Cellular Component: cytoplasm; endoplasmic reticulum; endosome; extracellular space; integral to plasma membrane; lysosome; nucleus; plasma membrane; receptor complex

Molecular Function: ATPase binding; identical protein binding; lutropin-choriogonadotropic hormone receptor activity; peptide hormone binding; peptide receptor activity, G-protein coupled; protein homodimerization activity

Biological Process: adenylate cyclase activation; arachidonic acid secretion; central nervous system development; cognition; development of secondary male sexual characteristics; female gonad development; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); hormone-mediated signaling; luteinizing hormone signaling pathway; male gonad development; ovarian follicle development; ovulation cycle process; positive regulation of calcium-mediated signaling; positive regulation of hormone biosynthetic process; positive regulation of inositol trisphosphate biosynthetic process; positive regulation of release of sequestered calcium ion into cytosol; protein targeting to lysosome; regulation of steroid biosynthetic process; response to drug; spermatogenesis; uterus development