Human THPO Recombinant Protein – Cat# MBS965730

Thrombopoietin (THPO) Human Recombinant Protein

Name: THPO Recombinant Protein; Thrombopoietin; Human; MyBioSource
Brand: MyBioSource
SKU: MBS965730
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS965730

Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Thrombopoietin (THPO), Recombinant Protein

Full Product Name

Recombinant Human Thrombopoietin (THPO)

Product Gene Name

THPO recombinant protein

Sequence

SPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNEL

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

34.7 kDa

Sequence Positions

22-195aa, Partial

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

187950

3D Structure

ModBase 3D Structure for P40225

Species

Homo sapiens (Human)

Product Categories/Family for THPO recombinant protein

Cancer

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for THPO recombinant protein

"Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand." de Sauvage F.J., Hass P.E., Spencer S.D., Malloy B.E., Gurney A.L., Spencer S.A., Darbonne W.C., Henzel W.J., Wong S.C., Kuang W.-J., Oles K.J., Hultgren B., Solberg L.A. Jr., Goeddel D.V., Eaton D.L. Nature 369:533-538(1994)

Other Notes

Small volumes of THPO recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for THPO purchase

MBS965730 is a recombinant protein targeting THPO. Also known as Recombinant Human Thrombopoietin (THPO). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for THPO. It may not necessarily be applicable to this product.

NCBI GI #

4507493

NCBI GeneID

7066

NCBI Accession #

NP_000451.1

UniProt Primary Accession #

P40225

UniProt Secondary Accession #

Q13020; Q15790; Q15791; Q15792; A1L3Y0; B7ZLR8; B9EGA8

UniProt Related Accession #

P40225

GenBank Nucleotide #

NM_000460.3

NCBI Official Full Name

thrombopoietin isoform 1

NCBI Official Synonym Full Names

thrombopoietin

NCBI Official Symbol

THPO

NCBI Official Synonym Symbols

ML; TPO; MGDF; MKCSF; MPLLG; THCYT1

UniProt Protein Name

Thrombopoietin

UniProt Synonym Protein Names

C-mpl ligand; ML; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; Myeloproliferative leukemia virus oncogene ligand

Protein Family

Thrombopoietin

UniProt Gene Name

THPO

UniProt Synonym Gene Names

MGDF; ML; MGDF

NCBI Protein Information

thrombopoietin

NCBI Summary for THPO

Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]

Research Articles on THPO

1. These studies demonstrate that biallelic loss-of-function mutations in THPO cause bone marrow failure, which is unresponsive to transplant due to a hematopoietic cell-extrinsic mechanism.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with THPO recombinant protein

Reference Product	PubMed Publications
MPL recombinant protein	>34 publications with THPO and MPL
JAK2 recombinant protein	>4 publications with THPO and JAK2
STAT3 recombinant protein	>1 publications with THPO and STAT3

Pathways associated with THPO recombinant protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Platelet Aggregation (Plug Formation) Pathway antibodies	Platelet Aggregation (Plug Formation) Pathway Diagram
Platelet Activation, Signaling And Aggregation Pathway antibodies	Platelet Activation, Signaling And Aggregation Pathway Diagram

Diseases associated with THPO recombinant protein

Disease Name	Pubmed Publications
Thrombocytosis Antibodies	>11 publications with THPO and Thrombocytosis
Anemia Antibodies	>8 publications with THPO and Anemia
Hemorrhage Antibodies	>3 publications with THPO and Hemorrhage
Lung Neoplasms Antibodies	>3 publications with THPO and Lung Neoplasms
Disease Models, Animal Antibodies	>3 publications with THPO and Disease Models, Animal
Neurobehavioral Manifestations Antibodies	>2 publications with THPO and Neurobehavioral Manifestations
Growth Disorders Antibodies	>2 publications with THPO and Growth Disorders
Thrombocythemia, Essential Antibodies	>2 publications with THPO and Thrombocythemia, Essential
Precancerous Conditions Antibodies	>1 publications with THPO and Precancerous Conditions
Prenatal Injuries Antibodies	>1 publications with THPO and Prenatal Injuries

Organs/Tissues associated with THPO recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>7 publications with THPO and Liver
Connective Tissue Antibodies	>1 publications with THPO and Connective Tissue