Corticotropin-Releasing Factor Receptor 1 (CRHR1) Mouse Recombinant Protein

The protein encoded by this gene is a G-protein coupled receptor that binds corticotropin-releasing factor (CRH) and urocortin (UCN) with high affinity. The encoded protein upregulates adenylate cyclase activity and intracellular cAMP levels. This protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response, and obesity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

CRF-R1: a G-protein coupled receptor that specifically binds corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. Four splice-variant isoforms have been described.

Protein type: Receptor, GPCR; GPCR, family 2; Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: cell; dendrite; integral to membrane; trans-Golgi network; cytosol; intrinsic to plasma membrane; multivesicular body; cell soma; membrane; apical part of cell; plasma membrane; vesicle; endosome

Molecular Function: G-protein coupled receptor activity; signal transducer activity; corticotropin-releasing hormone binding; transmembrane receptor activity; corticotropin-releasing hormone receptor activity; protein complex binding; G-protein alpha-subunit binding; corticotrophin-releasing factor receptor activity; peptide binding

Biological Process: fear response; hormone-mediated signaling; regulation of synaptic plasticity; behavioral response to ethanol; signal transduction; G-protein signaling, adenylate cyclase activating pathway; elevation of cytosolic calcium ion concentration; behavioral response to pain; general adaptation syndrome, behavioral process; cell surface receptor linked signal transduction; epithelial cell differentiation; behavioral response to cocaine; neuropeptide signaling pathway; positive regulation of cAMP biosynthetic process; visual learning; feeding behavior; response to electrical stimulus; adrenal gland development; positive regulation of mast cell degranulation; memory; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; adrenocorticotropin hormone secretion; response to hypoxia; negative regulation of epinephrine secretion; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)