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Kappa-Type Opioid Receptor (OPRK1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS965948

MBS965948 is a recombinant protein targeting Oprk1. Also known as Recombinant Mouse Kappa-type opioid receptor (Oprk1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Kappa-type opioid receptor (Oprk1), Recombinant Protein
Full Product Name
Recombinant Mouse Kappa-type opioid receptor (Oprk1)
Product Gene Name
Oprk1 recombinant protein
Product Synonym Gene Name
Oprk1
Product Synonym Names
Recombinant Kappa-type opioid receptor (Oprk1); Kappa-type opioid receptor; K-OR-1; KOR-1; MSL-1
Sequence
MESPIQIFRG DPGPTCSPSA CLLPNSSSWF PNWAESDSNG SVGSEDQQLE SAHISPAIPV IITAVYSVVF VVGLVGNSLV MFVIIRYTKM KTATNIYIFN LALADALVTT TMPFQSAVYL MNSWPFGDVL CKIVISIDYY NMFTSIFTLT MMSVDRYIAV CHPVKALDFR TPLKAKIINI CIWLLASSVG ISAIVLGGTK VREDVDVIEC SLQFPDDEYS WWDLFMKICV FVFAFVIPVL IIIVCYTLMI LRLKSVRLLS GSREKDRNLR RITKLVLVVV AVFIICWTPI HIFILVEALG STSHSTAALS SYYFCIALGY TNSSLNPVLY AFLDENFKRC FRDFCFPIKM RMERQSTNRV RNTVQDPASM RDVGGMNKPV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
42,652 Da
Sequence Positions
1-380
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 1; NC_000067.6 (5588493..5606133). Location: 1 A2-A3; 1 1.89 cM
3D Structure
ModBase 3D Structure for P33534
Species
Mus musculus (Mouse)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Oprk1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Oprk1. It may not necessarily be applicable to this product.

NCBI GI #
324120905
NCBI GeneID
18387
NCBI Accession #
NP_001191300.1
UniProt Primary Accession #
P33534
UniProt Related Accession #
P33534
GenBank Nucleotide #
NM_001204371.1
NCBI Official Full Name
kappa-type opioid receptor
NCBI Official Synonym Full Names
opioid receptor, kappa 1
NCBI Official Symbol
Oprk1
NCBI Official Synonym Symbols
KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1
UniProt Protein Name
Kappa-type opioid receptor
UniProt Synonym Protein Names
MSL-1
Protein Family
Kappa-type opioid receptor
UniProt Gene Name
Oprk1
UniProt Synonym Gene Names
K-OR-1; KOR-1
UniProt Entry Name
OPRK_MOUSE
NCBI Protein Information
kappa-type opioid receptor; opioid receptor, kappa 2

UniProt Comments for Oprk1

KOR-1: kappa-type opioid receptor. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: neuron projection; membrane; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; neuropeptide binding; signal transducer activity; opioid receptor activity

Biological Process: synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; behavior; opioid receptor, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); locomotory behavior; immune response; regulation of saliva secretion; signal transduction; sensory perception of pain; defense response to virus
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Research Articles on Oprk1

1. these data suggest that endogenous prodynorphin-derived peptides sufficiently activate KOP receptors during acute seizures, and importantly in situations of reduced dynorphinergic signaling-like in epilepsy-the exogenous activation of KOP receptors might also have strong neuroprotective effects during excitotoxic events.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Oprk1 recombinant protein

 Reference Product  PubMed Publications
 Oprd1 recombinant protein  >14 publications with Oprk1 and Oprd1

Pathways associated with Oprk1 recombinant protein

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with Oprk1 recombinant protein

 Disease Name  Pubmed Publications
 Substance-Related Disorders Antibodies  >13 publications with Oprk1 and Substance-Related Disorders
 Opioid-Related Disorders Antibodies  >9 publications with Oprk1 and Opioid-Related Disorders
 Heroin Dependence Antibodies  >8 publications with Oprk1 and Heroin Dependence
 Pain Antibodies  >8 publications with Oprk1 and Pain
 Nervous System Diseases Antibodies  >3 publications with Oprk1 and Nervous System Diseases
 Cocaine-Related Disorders Antibodies  >2 publications with Oprk1 and Cocaine-Related Disorders
 Anxiety Disorders Antibodies  >1 publications with Oprk1 and Anxiety Disorders
 Vomiting Antibodies  >1 publications with Oprk1 and Vomiting
 Drug Toxicity Antibodies  >1 publications with Oprk1 and Drug Toxicity
 Nausea Antibodies  >1 publications with Oprk1 and Nausea

Organs/Tissues associated with Oprk1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with Oprk1 and Brain
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