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Cytochrome P450 4f8 (CYP4F8) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS966386

MBS966386 is a recombinant protein targeting CYP4F8. Also known as Recombinant Human Cytochrome P450 4F8 (CYP4F8). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cytochrome P450 4F8 (CYP4F8), Recombinant Protein
Full Product Name
Recombinant Human Cytochrome P450 4F8 (CYP4F8)
Product Gene Name
CYP4F8 recombinant protein
Product Synonym Gene Name
CYP4F8
Product Synonym Names
Recombinant Cytochrome P450 4F8 (CYP4F8); Cytochrome P450 4F8 EC= 1.14.14.1; CYPIVF8
Sequence
MSLLSLSWLG LRPVAASPWL LLLVVGASWL LARILAWTYA FYHNGRRLRC FPQPRKQNWF LGHLGLVTPT EEGLRVLTQL VATYPQGFVR WLGPITPIIN LCHPDIVRSV INTSDAITDK DIVFYKTLKP WLGDGLLLSV GDKWRHHRRL LTPAFHFNIL KPYIKIFSKS ANIMHAKWQR LAMEGSTCLD VFEHISLMTL DSLQKCIFSF DSNCQEKPSE YITAIMELSA LVVKRNNQFF RYKDFLYFLT PCGRRFHRAC RLVHDFTDAV IQERRRTLTS QGVDDFLQAK AKSKTLDFID VLLLSEDKNG KELSDEDIRA EADTFMFGGH DTTASGLSWV LYNLARHPEY QERCRQEVQE LLKDREPKEI EWDDLAQLPF LTMCLKESLR LHPPIPTFAR GCTQDVVLPD SRVIPKGNVC NINIFAIHHN PSVWPDPEVY DPFRFDPENA QKRSPMAFIP FSAGPRNCIG QKFAMAEMKV VLALTLLRFR ILPDHREPRR TPEIVLRAED GLWLRVEPLG
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
59,995 Da
Sequence Positions
1-520
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 19; NC_000019.9 (15726029..15740448). Location: 19p13.1
OMIM
611545
3D Structure
ModBase 3D Structure for P98187
Species
Homo sapiens (Human)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CYP4F8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CYP4F8. It may not necessarily be applicable to this product.

NCBI GI #
6005737
NCBI GeneID
11283
NCBI Accession #
NP_009184.1
UniProt Primary Accession #
P98187
UniProt Related Accession #
P98187
GenBank Nucleotide #
NM_007253.3
NCBI Official Full Name
cytochrome P450 4F8
NCBI Official Synonym Full Names
cytochrome P450, family 4, subfamily F, polypeptide 8
NCBI Official Symbol
CYP4F8
NCBI Official Synonym Symbols
CPF8; CYPIVF8
UniProt Protein Name
Cytochrome P450 4F8
UniProt Synonym Protein Names
CYPIVF8
Protein Family
Cytochrome
UniProt Gene Name
CYP4F8
UniProt Entry Name
CP4F8_HUMAN
NCBI Protein Information
cytochrome P450 4F8; microsomal monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IVF, polypeptide 8

NCBI Summary for CYP4F8

This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of prostaglandins in seminal vesicles. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F3, is approximately 18 kb away. [provided by RefSeq, Jul 2008]
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UniProt Comments for CYP4F8

CYP4F8: Hydroxylates arachidonic acid (20:4n-6) to (18R)- hydroxyarachidonate. Shows little activity against prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyzes omega-2 and omega-3-hydroxylation of PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and 7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3- hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid (22:5n-6). Catalyzes hydrxylation of PGI2 and carbaprostacyclin. Belongs to the cytochrome P450 family.

Protein type: EC 1.14.14.1; Oxidoreductase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: iron ion binding; heme binding; alkane 1-monooxygenase activity

Biological Process: xenobiotic metabolic process; icosanoid metabolic process; prostaglandin metabolic process
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Research Articles on CYP4F8

1. The PLA2G7, HPGD, EPHX2, and CYP4F8 genes are highly expressed in prostate cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CYP4F8 recombinant protein

 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Eicosanoids Pathway antibodies  Eicosanoids Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Phase 1 - Functionalization Of Compounds Pathway antibodies  Phase 1 - Functionalization Of Compounds Pathway Diagram

Diseases associated with CYP4F8 recombinant protein

 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >2 publications with CYP4F8 and Skin Diseases
 Psoriasis Antibodies  >2 publications with CYP4F8 and Psoriasis
 Ichthyosis Antibodies  >1 publications with CYP4F8 and Ichthyosis

Organs/Tissues associated with CYP4F8 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >3 publications with CYP4F8 and Intestine
 Skin Antibodies  >3 publications with CYP4F8 and Skin
 Heart Antibodies  >2 publications with CYP4F8 and Heart
 Lung Antibodies  >1 publications with CYP4F8 and Lung
 Prostate Antibodies  >1 publications with CYP4F8 and Prostate
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