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Signal Transducer and Activator of Transcription 5b (STAT5B) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS966846

This protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell… More details

$1665 / 0.02 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Signal transducer and activator of transcription 5B (Stat5b), Recombinant Protein
Full Product Name
Recombinant Rat Signal transducer and activator of transcription 5B (Stat5b)
Product Gene Name
Stat5b recombinant protein
Sequence
MAMWIQAQQL QGDALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSIDLDN PQENIKATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV REANNGSSPA GSLADAMSQK HLQINQTFEE LRLITQDTES ELKKLQQTQE YFIIQYQESL RIQAQFAQLA QLNPQERMSR ETALQQKQVS LETWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRLEHLC QQLPIPGPVE EMLAEVNATI TDIISALSTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC CVMEYHQATG TLSAHFRNMS LKRIKRSDRR GAESVTEEKF TILFDSQFSV GGNELVFQVK TLSLPVVVIV HGSQDNNATA TVLWDNAFRE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNS SSNHLEDYNS MSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD FSIRSLADRL GDLNYLIYVF PDRPKDEVYS KYYTPVPCER ATAKAADGYV KPQIKQVVPE FVNASTDAGS GATYMDQAPS PVVCPQAHYN MYPQNPDSVL DTDGDFDLED TMDVARRVEE LLGRPMDSQW IPHAQS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
90,223 Da
Sequence Positions
1-786, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P52632
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Stat5b recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Stat5b purchase

MBS966846 is a recombinant protein targeting Stat5b. Also known as Recombinant Rat Signal transducer and activator of transcription 5B (Stat5b). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Stat5b. It may not necessarily be applicable to this product.

NCBI GI #
11693140
NCBI GeneID
25126
NCBI Accession #
NP_071775.1
UniProt Primary Accession #
P52632
UniProt Related Accession #
P52632
GenBank Nucleotide #
NM_022380.1
NCBI Official Full Name
signal transducer and activator of transcription 5B
NCBI Official Synonym Full Names
signal transducer and activator of transcription 5B
NCBI Official Symbol
Stat5b
UniProt Protein Name
Signal transducer and activator of transcription 5B
Protein Family
Signal transducer and activator of transcription
UniProt Gene Name
Stat5b
NCBI Protein Information
signal transducer and activator of transcription 5B

NCBI Summary for Stat5b

member of the STAT family of transcription factors; may mediate biological actions of several interleukins and growth hormones; may be associated with mammary gland development and lactation [RGD, Feb 2006]

UniProt Comments for Stat5b

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.

Research Articles on Stat5b

1. Combinatorial interplay among multiple Stat5b-binding response elements with distinguishable biochemical properties is responsible for highly regulated control of IGF-I gene activity by growth hormone.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Stat5b recombinant protein

 Reference Product  PubMed Publications
 Jak2 recombinant protein  >156 publications with Stat5b and Jak2
 Ghr recombinant protein  >60 publications with Stat5b and Ghr
 Prl recombinant protein  >47 publications with Stat5b and Prl
 Jak1 recombinant protein  >41 publications with Stat5b and Jak1
 Jak3 recombinant protein  >37 publications with Stat5b and Jak3
 Egfr recombinant protein  >26 publications with Stat5b and Egfr
 Tyk2 recombinant protein  >18 publications with Stat5b and Tyk2
 Epor recombinant protein  >8 publications with Stat5b and Epor

Pathways associated with Stat5b recombinant protein

 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 EPO Receptor Signaling Pathway antibodies  EPO Receptor Signaling Pathway Diagram

Diseases associated with Stat5b recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >148 publications with Stat5b and Neoplasms
 Breast Neoplasms Antibodies  >37 publications with Stat5b and Breast Neoplasms
 Carcinoma Antibodies  >32 publications with Stat5b and Carcinoma
 Inflammation Antibodies  >26 publications with Stat5b and Inflammation
 Kidney Diseases Antibodies  >23 publications with Stat5b and Kidney Diseases
 Liver Diseases Antibodies  >21 publications with Stat5b and Liver Diseases
 Lymphoma Antibodies  >21 publications with Stat5b and Lymphoma
 Necrosis Antibodies  >15 publications with Stat5b and Necrosis
 Adenocarcinoma Antibodies  >15 publications with Stat5b and Adenocarcinoma
 Autoimmune Diseases Antibodies  >12 publications with Stat5b and Autoimmune Diseases

Organs/Tissues associated with Stat5b recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >26 publications with Stat5b and Kidney
 Muscle Antibodies  >21 publications with Stat5b and Muscle
 Heart Antibodies  >21 publications with Stat5b and Heart
 Lung Antibodies  >19 publications with Stat5b and Lung
 Pancreas Antibodies  >11 publications with Stat5b and Pancreas
 Prostate Antibodies  >11 publications with Stat5b and Prostate
 Ovary Antibodies  >9 publications with Stat5b and Ovary
 Pituitary Gland Antibodies  >5 publications with Stat5b and Pituitary Gland
 Connective Tissue Antibodies  >4 publications with Stat5b and Connective Tissue
 Placenta Antibodies  >4 publications with Stat5b and Placenta
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