Rat PSMB4 Recombinant Protein – Cat# MBS967187

Proteasome Subunit Beta Type-4 (PSMB4) Rat Recombinant Protein

Name: PSMB4 Recombinant Protein; Proteasome Subunit Beta Type-4; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS967187
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS967187

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta… More details

$875 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Proteasome subunit beta type-4 (Psmb4), Recombinant Protein

Full Product Name

Recombinant Rat Proteasome subunit beta type-4 (Psmb4)

Product Gene Name

Psmb4 recombinant protein

Sequence

TQNPMVTGTS VLGVKFDCGV VIAADMLGSY GSLARFRNIS RIMRVNDSTM LGASGDYADF QYLKQVLGQM VIDEELFGDG HSYSPRAIHS WLTRAMYSRR SKMNPLWNTK VIGGYAGGES FLGYVDMLGV AYEAPSLATG YGAYLAQPLL REVLEKQPVL SQTEARELVE RCMRVLYYRD ARSYNRFQVA TVTEKGVEIE GPLSAQTNWD IAHMISGFE

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

29,197 Da

Sequence Positions

45-263, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P34067

Species

Rat

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Psmb4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Psmb4 purchase

MBS967187 is a recombinant protein targeting Psmb4. Also known as Recombinant Rat Proteasome subunit beta type-4 (Psmb4). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Psmb4. It may not necessarily be applicable to this product.

NCBI GI #

3915806

NCBI GeneID

58854

NCBI Accession #

P34067.2

UniProt Primary Accession #

P34067

UniProt Secondary Accession #

P28071; P97719

UniProt Related Accession #

P34067

NCBI Official Full Name

Proteasome subunit beta type-4

NCBI Official Synonym Full Names

proteasome subunit beta 4

NCBI Official Symbol

Psmb4

UniProt Protein Name

Proteasome subunit beta type-4

UniProt Synonym Protein Names

Macropain beta chain; Multicatalytic endopeptidase complex beta chain; Proteasome beta chain; Proteasome chain 3; RN3

Protein Family

Proteasome

UniProt Gene Name

Psmb4

UniProt Synonym Gene Names

RN3

NCBI Protein Information

proteasome subunit beta type-4

NCBI Summary for Psmb4

beta-type subgroup component of the proteasome multicatalytic proteinase complex [RGD, Feb 2006]

UniProt Comments for Psmb4

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.

Research Articles on Psmb4

1. that PSMB4 is associated with RIP3 involved necroptosis after Spinal cord injury

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Psmb4 recombinant protein

Reference Product	PubMed Publications
Psmb5 recombinant protein	>3 publications with Psmb4 and Psmb5
Psma6 recombinant protein	>2 publications with Psmb4 and Psma6
Psma1 recombinant protein	>2 publications with Psmb4 and Psma1
Psmb2 recombinant protein	>2 publications with Psmb4 and Psmb2
Psmb6 recombinant protein	>1 publications with Psmb4 and Psmb6
Psma5 recombinant protein	>1 publications with Psmb4 and Psma5

Pathways associated with Psmb4 recombinant protein

Products by Pathway	Pathway Diagram
APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies	APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies	APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies	APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies	APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies	APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
ARMS-mediated Activation Pathway antibodies	ARMS-mediated Activation Pathway Diagram
AUF1 (hnRNP D0) Destabilizes MRNA Pathway antibodies	AUF1 (hnRNP D0) Destabilizes MRNA Pathway Diagram
Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies	Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
Activation Of NF-kappaB In B Cells Pathway antibodies	Activation Of NF-kappaB In B Cells Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram

Diseases associated with Psmb4 recombinant protein

Disease Name	Pubmed Publications
Carcinoma Antibodies	>6 publications with Psmb4 and Carcinoma
Adenocarcinoma Antibodies	>5 publications with Psmb4 and Adenocarcinoma
Carcinoma, Hepatocellular Antibodies	>3 publications with Psmb4 and Carcinoma, Hepatocellular
Liver Diseases Antibodies	>2 publications with Psmb4 and Liver Diseases
Cardiovascular Diseases Antibodies	>2 publications with Psmb4 and Cardiovascular Diseases
Neoplasm Metastasis Antibodies	>2 publications with Psmb4 and Neoplasm Metastasis
Inflammation Antibodies	>2 publications with Psmb4 and Inflammation
Liver Neoplasms Antibodies	>2 publications with Psmb4 and Liver Neoplasms
Cell Transformation, Neoplastic Antibodies	>1 publications with Psmb4 and Cell Transformation, Neoplastic
Heart Diseases Antibodies	>1 publications with Psmb4 and Heart Diseases

Organs/Tissues associated with Psmb4 recombinant protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>4 publications with Psmb4 and Muscle
Heart Antibodies	>2 publications with Psmb4 and Heart
Prostate Antibodies	>2 publications with Psmb4 and Prostate
Brain Antibodies	>2 publications with Psmb4 and Brain
Liver Antibodies	>2 publications with Psmb4 and Liver
Placenta Antibodies	>1 publications with Psmb4 and Placenta
Kidney Antibodies	>1 publications with Psmb4 and Kidney
Lung Antibodies	>1 publications with Psmb4 and Lung