CD44 Antigen (CD44) Human Recombinant Protein

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hatopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family.Stamenkovic I., Amiot M., Pesando J.M., Seed B.Cell 56:1057-1062(1989) The multispecific cell adhesion molecule CD44 is represented in reticulocyte cDNA.Harn H.-J., Isola N., Cooper D.L.Biochem. Biophys. Res. Commun. 178:1127-1134(1991) The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells.Stamenkovic I., Aruffo A., Amiot M., Seed B.EMBO J. 10:343-348(1991) Molecular cloning of CD44R1 and CD44R2, two novel isoforms of the human CD44 lymphocyte 'homing' receptor expressed by hemopoietic cells.Dougherty G.J., Lansdorp P.M., Cooper D.L., Humphries R.K.J. Exp. Med. 174:1-5(1991) The core protein of epican, a heparan sulfate proteoglycan on keratinocytes, is an alternative form of CD44.Kugelman L.C., Ganguly S., Haggerty J.G., Weissman S.M., Milstone L.M.J. Invest. Dermatol. 99:886-891(1992) Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.Screaton G.R., Bell M.V., Jackson D.G., Cornelis F.B., Gerth U., Bell J.I.Proc. Natl. Acad. Sci. U.S.A. 89:12160-12164(1992) CD44 a multitude of isoforms with diverse functions.Gunthert U.Curr. Top. Microbiol. Immunol. 184:47-63(1993) Novel variants of CD44 arising from alternative splicing changes in the CD44 alternative splicing pattern of MCF-7 breast carcinoma cells treated with hyaluronidase.Tanabe K.K., Nishi T., Saya H.Mol. Carcinog. 7:212-220(1993) Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44.Chiu R.K., Carpenito C., Dougherty S.T., Hayes G.M., Dougherty G.J.Neoplasia 1:446-452(1999) CD44 in normal and neoplastic human cartilage.Bosch P.P., Stevens J.W., Buckwalter J.A., Midura R.J. Sequence analysis of the human CD44 antigen.Wiebe G.J., Freund D., Corbeil D. Sequence analysis of a novel human CD44 variant.Xiang Q., Wang J., Fan C., He X., Huang L., Zhu H., Qiu X., Luo W.Construction of human CD44 eukaryotic vector and its expression in mammary carcinoma cells MCF-7.Fang X., Xu W., Zhang X.The full-ORF clone resource of the German cDNA consortium.Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.BMC Genomics 8:399-399(2007) Human chromosome 11 DNA sequence and analysis including novel gene identification.Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.Nature 440:497-500(2006)

Small volumes of CD44 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS967245 is a recombinant protein targeting CD44. Also known as Recombinant Human CD44 antigen (CD44), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.