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Gap Junction Alpha-1 Protein (GJA1) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS967257

MBS967257 is a recombinant protein targeting Gja1. Also known as Recombinant Rat Gap junction alpha-1 protein (Gja1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Gap junction alpha-1 protein (Gja1), Recombinant Protein
Full Product Name
Recombinant Rat Gap junction alpha-1 protein (Gja1)
Product Gene Name
Gja1 recombinant protein
Product Synonym Gene Name
Gja1; Cxn-43
Product Synonym Names
Recombinant Gap junction alpha-1 protein (Gja1); Gap junction alpha-1 protein; Connexin-43; Cx43 Gap junction 43 kDa heart protein
Sequence
GDWSALGKLL DKVQAYSTAG GKVWLSVLFI FRILLLGTAV ESAWGDEQSA FRCNTQQPGC ENVCYDKSFP ISHVRFWVLQ IIFVSVPTLL YLAHVFYVMR KEEKLNKKEE ELKVAQTDGV NVEMHLKQIE IKKFKYGIEE HGKVKMRGGL LRTYIISILF KSVFEVAFLL IQWYIYGFSL SAVYTCKRDP CPHQVDCFLS RPTEKTIFII FMLVVSLVSL ALNIIELFYV FFKGVKDRVK GRSDPYHATT GPLSPSKDCG SPKYAYFNGC SSPTAPLSPM SPPGYKLVTG DRNNSSCRNY NKQASEQNWA NYSAEQNRMG QAGSTISNSH AQPFDFPDDN QNAKKVAAGH ELQPLAIVDQ RPSSRASSRA SSRPRPDDLE I
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
43,031 Da
Sequence Positions
2-382
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 20; NC_005119.3 (39612108..39624555). Location: 20q11
3D Structure
ModBase 3D Structure for P08050
Species
Rattus norvegicus (Rat)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Gja1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Gja1. It may not necessarily be applicable to this product.

NCBI GI #
6978896
NCBI GeneID
24392
NCBI Accession #
NP_036699.1
UniProt Primary Accession #
P08050
UniProt Secondary Accession #
Q53ZE1
UniProt Related Accession #
P08050
GenBank Nucleotide #
NM_012567.2
NCBI Official Full Name
gap junction alpha-1 protein
NCBI Official Synonym Full Names
gap junction protein, alpha 1
NCBI Official Symbol
Gja1
NCBI Official Synonym Symbols
Cx43
UniProt Protein Name
Gap junction alpha-1 protein
UniProt Synonym Protein Names
Connexin-43; Cx43; Gap junction 43 kDa heart protein
Protein Family
Gap junction alpha-1 protein
UniProt Gene Name
Gja1
UniProt Synonym Gene Names
Cxn-43; Cx43
UniProt Entry Name
CXA1_RAT
NCBI Protein Information
gap junction alpha-1 protein; connexin 43; connexin-43; gap junction 43 kDa heart protein; gap junction membrane channel protein alpha 1

NCBI Summary for Gja1

gap junction component; plays a role in cell-cell communication [RGD, Feb 2006]

UniProt Comments for Gja1

GJA1: an integral membrane protein of the connexin family, alpha-type (group II) subfamily. Hexamers of connexin-43 form connexons, which aggregate together to form gap junctions, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.

Protein type: Membrane protein, multi-pass; Channel, misc.; Membrane protein, integral; Motility/polarity/chemotaxis

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; focal adhesion; contractile fiber; integral to plasma membrane; lysosome; early endosome; intermediate filament; fascia adherens; intercellular junction; cytosol; lipid raft; Golgi membrane; multivesicular body; connexon complex; mitochondrial outer membrane; membrane; cytoplasm; late endosome; apical plasma membrane; gap junction; plasma membrane; cell junction; lateral plasma membrane; endosome

Molecular Function: protein domain specific binding; protein binding; signal transducer activity; ion transmembrane transporter activity; beta-tubulin binding; SH3 domain binding; gap junction channel activity; receptor binding; PDZ domain binding

Biological Process: lens development in camera-type eye; response to peptide hormone stimulus; apoptosis; heart development; neuron migration; milk ejection; signal transduction; positive regulation of vasodilation; regulation of heart contraction; negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; cell-cell signaling; positive regulation of glomerular filtration; negative regulation of cardiac muscle cell proliferation; response to glucose stimulus; positive regulation of striated muscle development; cell communication; heart looping; transmembrane transport; adult heart development; ATP transport; intercellular junction assembly and maintenance; chronic inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; gap junction assembly; epithelial cell maturation; in utero embryonic development; regulation of bone remodeling; skeletal muscle regeneration; positive regulation of insulin secretion; regulation of calcium ion transport; vascular transport; protein oligomerization; osteoblast differentiation; positive regulation of osteoblast differentiation; negative regulation of endothelial cell proliferation; positive regulation of protein catabolic process; positive regulation of vasoconstriction; embryonic heart tube development; blood vessel morphogenesis; embryonic digit morphogenesis; regulation of bone mineralization; neurite morphogenesis; response to pH
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Research Articles on Gja1

1. Mitochondrial Cx43 is required for optimal complex I activity and respiration and thus mitochondrial ATP-production.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Gja1 recombinant protein

 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Formation Of Annular Gap Junctions Pathway antibodies  Formation Of Annular Gap Junctions Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Assembly Pathway antibodies  Gap Junction Assembly Pathway Diagram
 Gap Junction Degradation Pathway antibodies  Gap Junction Degradation Pathway Diagram
 Gap Junction Trafficking Pathway antibodies  Gap Junction Trafficking Pathway Diagram

Diseases associated with Gja1 recombinant protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >47 publications with Gja1 and Cardiovascular Diseases
 OCULODENTODIGITAL DYSPLASIA Antibodies  >45 publications with Gja1 and OCULODENTODIGITAL DYSPLASIA
 Heart Diseases Antibodies  >42 publications with Gja1 and Heart Diseases
 Neoplasms Antibodies  >32 publications with Gja1 and Neoplasms
 Nervous System Diseases Antibodies  >29 publications with Gja1 and Nervous System Diseases
 Arrhythmias, Cardiac Antibodies  >27 publications with Gja1 and Arrhythmias, Cardiac
 Disease Models, Animal Antibodies  >25 publications with Gja1 and Disease Models, Animal
 Skin Diseases Antibodies  >14 publications with Gja1 and Skin Diseases
 Myocardial Ischemia Antibodies  >10 publications with Gja1 and Myocardial Ischemia
 Heart Defects, Congenital Antibodies  >9 publications with Gja1 and Heart Defects, Congenital

Organs/Tissues associated with Gja1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >60 publications with Gja1 and Heart
 Muscle Antibodies  >58 publications with Gja1 and Muscle
 Eye Antibodies  >49 publications with Gja1 and Eye
 Brain Antibodies  >26 publications with Gja1 and Brain
 Ovary Antibodies  >15 publications with Gja1 and Ovary
 Embryonic Tissue Antibodies  >11 publications with Gja1 and Embryonic Tissue
 Lung Antibodies  >10 publications with Gja1 and Lung
 Kidney Antibodies  >9 publications with Gja1 and Kidney
 Prostate Antibodies  >5 publications with Gja1 and Prostate
 Liver Antibodies  >4 publications with Gja1 and Liver
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