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POU Domain, Class 3, Transcription Factor 4 (POU3F4) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS967324

This gene encodes a member of the POU-III class of neural transcription factors. This gene may play a role in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations have been associated with X chromosome-linked… More details

$1080 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
POU domain, class 3, transcription factor 4 (POU3F4), Recombinant Protein
Full Product Name
Recombinant Human POU domain, class 3, transcription factor 4 (POU3F4)
Product Gene Name
POU3F4 recombinant protein
Sequence
MATAASNPYS ILSSTSLVHA DSAGMQQGSP FRNPQKLLQS DYLQGVPSNG HPLGHHWVTS LSDGGPWSST LATSPLDQQD VKPGREDLQL GAIIHHRSPH VAHHSPHTNH PNAWGASPAP NPSITSSGQP LNVYSQPGFT VSGMLEHGGL TPPPAAASAQ SLHPVLREPP DHGELGSHHC QDHSDEETPT SDELEQFAKQ FKQRRIKLGF TQADVGLALG TLYGNVFSQT TICRFEGLQL SFKNMCKLKP LLNKWLEEAD SSTGSPTSID KIAAQGRKRK KRTSIEVSVK GVLETHFLKC PKPAAQEISS LADSLQLEKE VVRVWFCNRR QKEKRMTPPG DQQPHEVYSH TVKTDTSCHD L
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
39,427 Da
Sequence Positions
1-361, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
300039
3D Structure
ModBase 3D Structure for P49335
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of POU3F4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for POU3F4 purchase

MBS967324 is a recombinant protein targeting POU3F4. Also known as Recombinant Human POU domain, class 3, transcription factor 4 (POU3F4). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for POU3F4. It may not necessarily be applicable to this product.

NCBI GI #
433288480
NCBI GeneID
5456
NCBI Accession #
NP_000298.3
UniProt Primary Accession #
P49335
UniProt Secondary Accession #
Q5H9G9; Q99410; B2RC71
UniProt Related Accession #
P49335
GenBank Nucleotide #
NM_000307.4
NCBI Official Full Name
POU domain, class 3, transcription factor 4
NCBI Official Synonym Full Names
POU class 3 homeobox 4
NCBI Official Symbol
POU3F4
NCBI Official Synonym Symbols
BRN4; DFN3; OTF9; BRN-4; DFNX2; OCT-9; OTF-9; BRAIN-4
UniProt Protein Name
POU domain, class 3, transcription factor 4
UniProt Synonym Protein Names
Brain-specific homeobox/POU domain protein 4; Brain-4; Brn-4; Octamer-binding protein 9; Oct-9; Octamer-binding transcription factor 9; OTF-9
Protein Family
POU domain, class 3, transcription factor
UniProt Gene Name
POU3F4
UniProt Synonym Gene Names
BRN4; OTF9; Brain-4; Brn-4; Oct-9; OTF-9
NCBI Protein Information
POU domain, class 3, transcription factor 4

NCBI Summary for POU3F4

This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012]
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UniProt Comments for POU3F4

Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain.

Research Articles on POU3F4

1. POU3F4 mutations can be predicted by incomplete partition type III anomaly by radiological examination of the inner ear. All six of the patients showed mixed hearing loss, but none showed fluctuations in hearing, which may be related to the lack of vestibular aqueduct enlargement at the operculum.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with POU3F4 recombinant protein

 Reference Product  PubMed Publications
 POU3F3 recombinant protein  >2 publications with POU3F4 and POU3F3
 POU3F2 recombinant protein  >1 publications with POU3F4 and POU3F2
 POU3F1 recombinant protein  >1 publications with POU3F4 and POU3F1

Diseases associated with POU3F4 recombinant protein

 Disease Name  Pubmed Publications
 Hearing Loss, Sensorineural Antibodies  >19 publications with POU3F4 and Hearing Loss, Sensorineural
 Neoplasms Antibodies  >2 publications with POU3F4 and Neoplasms
 Adenoma Antibodies  >1 publications with POU3F4 and Adenoma
 Anemia Antibodies  >1 publications with POU3F4 and Anemia
 Delirium, Dementia, Amnestic, Cognitive Disorders Antibodies  >1 publications with POU3F4 and Delirium, Dementia, Amnestic, Cognitive Disorders
 Progressive hearing loss stapes fixation Antibodies  >1 publications with POU3F4 and Progressive hearing loss stapes fixation

Organs/Tissues associated with POU3F4 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >30 publications with POU3F4 and Brain
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