Filaggrin (FLG) Human Recombinant Protein

Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.

The DNA sequence and biological annotation of human chromosome 1.Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.Nature 441:315-321(2006) Characterization of the human epidermal profilaggrin gene. Genomic organization and identification of an S-100-like calcium binding domain at the amino terminus.Presland R.B., Haydock P.V., Fleckman P., Nirunsuksiri W., Dale B.A.J. Biol. Chem. 267:23772-23781(1992) Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21.McKinley-Grant L.J., Idler W.W., Bernstein I.A., Parry D.A.D., Cannizzaro L., Croce C.M., Huebner K., Lessin S.R., Steinert P.M.Proc. Natl. Acad. Sci. U.S.A. 86:4848-4852(1989) Identification of the amino terminus of human filaggrin using differential LC/MS techniques implications for profilaggrin processing.Thulin C.D., Walsh K.A.Biochemistry 34:8687-8692(1995) Preferential deimination of keratin K1 and filaggrin during the terminal differentiation of human epidermis.Senshu T., Kan S., Ogawa H., Manabe M., Asaga H.Biochem. Biophys. Res. Commun. 225:712-719(1996) Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations.Weidinger S., Illig T., Baurecht H., Irvine A.D., Rodriguez E., Diaz-Lacava A., Klopp N., Wagenpfeil S., Zhao Y., Liao H., Lee S.P., Palmer C.N.A., Jenneck C., Maintz L., Hagemann T., Behrendt H., Ring J., Nothen M.M., McLean W.H.I., Novak N.J. Allergy Clin. Immunol. 118:214-219(2006) Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march.Marenholz I., Nickel R., Rueschendorf F., Schulz F., Esparza-Gordillo J., Kerscher T., Grueber C., Lau S., Worm M., Keil T., Kurek M., Zaluga E., Wahn U., Lee Y.-A.J. Allergy Clin. Immunol. 118:866-871(2006) Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris.Smith F.J.D., Irvine A.D., Terron-Kwiatkowski A., Sandilands A., Campbell L.E., Zhao Y., Liao H., Evans A.T., Goudie D.R., Lewis-Jones S., Arseculeratne G., Munro C.S., Sergeant A., O'Regan G., Bale S.J., Compton J.G., DiGiovanna J.J., Presland R.B., Fleckman P., McLean W.H.I.Nat. Genet. 38:337-342(2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis.Palmer C.N.A., Irvine A.D., Terron-Kwiatkowski A., Zhao Y., Liao H., Lee S.P., Goudie D.R., Sandilands A., Campbell L.E., Smith F.J.D., O'Regan G.M., Watson R.M., Cecil J.E., Bale S.J., Compton J.G., DiGiovanna J.J., Fleckman P., Lewis-Jones S., Arseculeratne G., Sergeant A., Munro C.S., El Houate B., McElreavey K., Halkjaer L.B., Bisgaard H., Mukhopadhyay S., McLean W.H.I.Nat. Genet. 38:441-446(2006) Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis.Nomura T., Sandilands A., Akiyama M., Liao H., Evans A.T., Sakai K., Ota M., Sugiura H., Yamamoto K., Sato H., Palmer C.N.A., Smith F.J.D., McLean W.H.I., Shimizu H.J. Allergy Clin. Immunol. 119:434-440(2007) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014)

Small volumes of FLG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS967523 is a recombinant protein targeting FLG. Also known as Recombinant Human Filaggrin (FLG), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.