5-Hydroxytryptamine Receptor 2a (HTR2A) Mouse Recombinant Protein

5-HT(2A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Cellular Component: cell projection; membrane; cell soma; integral to plasma membrane; cytoplasm; dendrite; plasma membrane; integral to membrane; dendritic shaft; cytoplasmic vesicle; cytosol

Molecular Function: G-protein coupled receptor activity; signal transducer activity; serotonin binding; serotonin receptor activity; protein complex binding; G-protein alpha-subunit binding; drug binding

Biological Process: urinary bladder smooth muscle contraction; cell death; phosphoinositide 3-kinase cascade; behavior; negative regulation of potassium ion transport; positive regulation of kinase activity; thermoregulation; signal transduction; sensory perception of pain; regulation of dopamine secretion; positive regulation of MAP kinase activity; elevation of cytosolic calcium ion concentration; smooth muscle contraction; behavioral response to cocaine; positive regulation of cell proliferation; detection of temperature stimulus involved in sensory perception of pain; artery smooth muscle contraction; serotonin receptor signaling pathway; regulation of behavior; response to drug; serotonin receptor, phospholipase C activating pathway; negative regulation of synaptic transmission, glutamatergic; regulation of hormone secretion; sleep; positive regulation of phosphatidylinositol biosynthetic process; memory; cellular calcium ion homeostasis; detection of mechanical stimulus involved in sensory perception of pain; G-protein coupled receptor protein signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; phospholipase C activation; release of sequestered calcium ion into cytosol; positive regulation of glycolysis; positive regulation of vasoconstriction; positive regulation of fat cell differentiation