Mouse DSC2 Recombinant Protein – Cat# MBS968047

Desmocollin-2 (DSC2) Mouse Recombinant Protein

Name: DSC2 Recombinant Protein; Desmocollin-2; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS968047
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS968047

MBS968047 is a recombinant protein targeting Dsc2. Also known as Recombinant Mouse Desmocollin-2 (Dsc2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Desmocollin-2 (Dsc2), Recombinant Protein

Full Product Name

Recombinant Mouse Desmocollin-2 (Dsc2)

Product Gene Name

Dsc2 recombinant protein

Product Synonym Gene Name

Dsc2; Dsc3

Product Synonym Names

Desmocollin-2; Epithelial type 2 desmocollin

Sequence

RWAPI PCSMLENSLG PFPLFLQQIQ SDTAQNYTIY YSIRGPGVDK EPLNLFYVER DTGNLYCTGR VDREQYESFE LTAFATTPDG YTPEYPLPLL IKIEDENDNY PIFTQKLYSF TVQENSRIGS IVGEVCATDL DEPDTMHTRL RYSILEQSPS PPMLFTMHPS TGVITTTSAQ LDRELIDKYQ LLIKVQDMDG QYFGLHTTAK CIITIEDVND NLPTFTRTTY VTSVEENTVN VEILRLTVQD KDLVNSPNWR ANYTILKGNE NGNFKIVTDP KTNEGILCVI KPLDYEERQQ VTLQIGVVNE APYTREASSK SPMSTATVTV TVTNQDEGPE CIPPMQTVRI QENVPVGTRN DGYKAYDPET RSSSGIRYRK LSDPRGWVTV NEDSGSITIF RALDREAETV RNGIYNITVL ALDADGRSCT GTLGIILEDV NDNGPFIPKQ TVVICKATMS SAEIVAVDLD DPVNGPPFDF SLESSDSEVQ RMWRLTRIND TAARLSYQND PSFGSYAVPI RVTDRLGLSS VTTLNVLVCD CITESDCTLR SGERTGYADV RLGP

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

93,957 Da

Sequence Positions

136-694

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P55292

Species

Mus musculus (Mouse)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Dsc2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Dsc2. It may not necessarily be applicable to this product.

NCBI GI #

7305007

NCBI GeneID

13506

NCBI Accession #

NP_038533.1

UniProt Primary Accession #

P55292

UniProt Secondary Accession #

Q64734

UniProt Related Accession #

P55292

GenBank Nucleotide #

NM_013505.3

NCBI Official Full Name

desmocollin-2

NCBI Official Synonym Full Names

desmocollin 2

NCBI Official Symbol

Dsc2

NCBI Official Synonym Symbols

Dsc2a; Dsc2b; AW228162

UniProt Protein Name

Desmocollin-2

UniProt Synonym Protein Names

Epithelial type 2 desmocollin

Protein Family

Desmocollin

UniProt Gene Name

Dsc2

UniProt Synonym Gene Names

Dsc3

UniProt Entry Name

DSC2_MOUSE

NCBI Protein Information

desmocollin-2; epithelial type 2 desmocollin

UniProt Comments for Dsc2

DSC2: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 (ARVD11); also known as arrhythmogenic right ventricular cardiomyopathy 11 (ARVC11). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Cellular Component: desmosome; cell-cell adherens junction; membrane; plasma membrane; integral to membrane; cytoplasmic vesicle; cell junction

Molecular Function: metal ion binding; calcium ion binding

Biological Process: cellular response to starvation; cell adhesion; homophilic cell adhesion

Research Articles on Dsc2

1. plakoglobin (Pg) in conjunction with lymphoid enhancer-binding factor 1 (Lef-1) differentially regulates the proximal promoters of Dsc2 and Dsc3

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Dsc2 recombinant protein

Products by Pathway	Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram

Diseases associated with Dsc2 recombinant protein

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>44 publications with Dsc2 and Heart Diseases
Heart Defects, Congenital Antibodies	>39 publications with Dsc2 and Heart Defects, Congenital
Heart Failure Antibodies	>9 publications with Dsc2 and Heart Failure
Lung Neoplasms Antibodies	>4 publications with Dsc2 and Lung Neoplasms
Neoplasm Metastasis Antibodies	>4 publications with Dsc2 and Neoplasm Metastasis
Liver Neoplasms Antibodies	>3 publications with Dsc2 and Liver Neoplasms
Inflammation Antibodies	>3 publications with Dsc2 and Inflammation
Liver Diseases Antibodies	>3 publications with Dsc2 and Liver Diseases
Arrhythmogenic Right Ventricular Dysplasia, Familial, 11 Antibodies	>3 publications with Dsc2 and Arrhythmogenic Right Ventricular Dysplasia, Familial, 11
Kidney Neoplasms Antibodies	>2 publications with Dsc2 and Kidney Neoplasms

Organs/Tissues associated with Dsc2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>35 publications with Dsc2 and Heart
Skin Antibodies	>22 publications with Dsc2 and Skin
Lung Antibodies	>6 publications with Dsc2 and Lung
Brain Antibodies	>3 publications with Dsc2 and Brain
Intestine Antibodies	>3 publications with Dsc2 and Intestine
Embryonic Tissue Antibodies	>3 publications with Dsc2 and Embryonic Tissue
Stomach Antibodies	>3 publications with Dsc2 and Stomach
Liver Antibodies	>3 publications with Dsc2 and Liver
Tongue Antibodies	>2 publications with Dsc2 and Tongue
Bladder Antibodies	>1 publications with Dsc2 and Bladder