Growth Arrest and DNA Damage-Inducible Protein GADD45 Alpha (GADD45A) Human Recombinant Protein

In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.

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CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle.Chung H.K., Yi Y.-W., Jung N.-C., Kim D., Suh J.M., Kim H., Park K.C., Song J.H., Kim D.W., Hwang E.S., Yoon S.-H., Bae Y.-S., Kim J.M., Bae I., Shong M.J. Biol. Chem. 278:28079-28088(2003) Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.Smith M.L., Chen I.-T., Zhan Q., Bae I., Chen C.-Y., Gilmer T.M., Kastan M.B., O'Connor P.M., Fornace A.J. Jr.Science 266:1376-1380(1994) Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase.Sanchez R., Pantoja-Uceda D., Prieto J., Diercks T., Marcaida M.J., Montoya G., Campos-Olivas R., Blanco F.J.J. Biol. Chem. 285:22196-22201(2010)

Small volumes of GADD45A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS968080 is a recombinant protein targeting GADD45A. Also known as Recombinant Human Growth arrest and DNA damage-inducible protein GADD45 alpha. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.