Human TCF4 Recombinant Protein – Cat# MBS968129

Transcription Factor 4 (TCF4) Human Recombinant Protein

Name: TCF4 Recombinant Protein; Transcription Factor 4; Human; MyBioSource
Brand: MyBioSource
SKU: MBS968129
Price: 1500 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS968129

This gene encodes transcription factor 4, a basic helix-turn-helix transcription factor. The encoded protein recognizes an Ephrussi-box ( E-box ) binding site ( CANNTG ) - a motif first identified in immunoglobulin enhancers. This gene is expressed… More details

$1500 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Transcription factor 4 (TCF4), Recombinant Protein

Full Product Name

Recombinant Human Transcription factor 4 (TCF4)

Product Gene Name

TCF4 recombinant protein

Sequence

MHHQQRMAAL GTDKELSDLL DFSAMFSPPV SSGKNGPTSL ASGHFTGSNV EDRSSSGSWG NGGHPSPSRN YGDGTPYDHM TSRDLGSHDN LSPPFVNSRI QSKTERGSYS SYGRESNLQG CHQQSLLGGD MDMGNPGTLS PTKPGSQYYQ YSSNNPRRRP LHSSAMEVQT KKVRKVPPGL PSSVYAPSAS TADYNRDSPG YPSSKPATST FPSSFFMQDG HHSSDPWSSS SGMNQPGYAG MLGNSSHIPQ SSSYCSLHPH ERLSYPSHSS ADINSSLPPM STFHRSGTNH YSTSSCTPPA NGTDSIMANR GSGAAGSSQT GDALGKALAS IYSPDHTNNS FSSNPSTPVG SPPSLSAGTA VWSRNGGQAS SSPNYEGPLH SLQSRIEDRL ERLDDAIHVL RNHAVGPSTA MPGGHGDMHG IIGPSHNGAM GGLGSGYGTG LLSANRHSLM VGTHREDGVA LRGSHSLLPN QVPVPQLPVQ SATSPDLNPP QDPYRGMPPG LQGQSVSSGS SEIKSDDEGD ENLQDTKSSE DKKLDDDKKD IKSITSNNDD EDLTPEQKAE REKERRMANN ARERLRVRDI NEAFKELGRM VQLHLKSDKP QTKLLILHQA VAVILSLEQQ VRERNLNPKA ACLKRREEEK VSSEPPPLSL AGPHPGMGDA SNHMGQM

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

48,098 Da

Sequence Positions

1-667, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

602272

3D Structure

ModBase 3D Structure for P15884

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TCF4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TCF4 purchase

MBS968129 is a recombinant protein targeting TCF4. Also known as Recombinant Human Transcription factor 4 (TCF4). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for TCF4. It may not necessarily be applicable to this product.

NCBI GI #

145312267

NCBI GeneID

6925

NCBI Accession #

NP_001077431.1

UniProt Primary Accession #

P15884

UniProt Secondary Accession #

B3KT62; B3KUC0; B4DT37; B4DUG3; B7Z5M6; B7Z6Y1; G0LNT9; G0LNU0; G0LNU1; G0LNU2; G0LNU4

UniProt Related Accession #

P15884

GenBank Nucleotide #

NM_001083962.1

NCBI Official Full Name

transcription factor 4 isoform a

NCBI Official Synonym Full Names

transcription factor 4

NCBI Official Symbol

TCF4

NCBI Official Synonym Symbols

E2-2; ITF2; PTHS; SEF2; FECD3; ITF-2; SEF-2; TCF-4; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; bHLHb19

UniProt Protein Name

Transcription factor 4

UniProt Synonym Protein Names

Class B basic helix-loop-helix protein 19; bHLHb19; Immunoglobulin transcription factor 2; ITF-2; SL3-3 enhancer factor 2; SEF-2

Protein Family

Transcription factor

UniProt Gene Name

TCF4

UniProt Synonym Gene Names

BHLHB19; ITF2; SEF2; TCF-4; bHLHb19; ITF-2; SEF-2

NCBI Protein Information

transcription factor 4

NCBI Summary for TCF4

This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016]

UniProt Comments for TCF4

Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.

Research Articles on TCF4

1. FOXN3 bind to beta-catenin and inhibited beta-catenin/TCF signaling by blocking the interaction between beta-catenin and TCF4. Loss of FOXN3 in colon cancer activates beta-catenin/TCF signaling and promotes the growth and migration of cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TCF4 recombinant protein

Reference Product	PubMed Publications
CTNNB1 recombinant protein	>620 publications with TCF4 and CTNNB1
ID2 recombinant protein	>12 publications with TCF4 and ID2
ID1 recombinant protein	>8 publications with TCF4 and ID1
ID3 recombinant protein	>6 publications with TCF4 and ID3
EP300 recombinant protein	>5 publications with TCF4 and EP300
TAL1 recombinant protein	>4 publications with TCF4 and TAL1
ATOH1 recombinant protein	>3 publications with TCF4 and ATOH1
HIVEP2 recombinant protein	>1 publications with TCF4 and HIVEP2

Pathways associated with TCF4 recombinant protein

Products by Pathway	Pathway Diagram
CDO In Myogenesis Pathway antibodies	CDO In Myogenesis Pathway Diagram
Coregulation Of Androgen Receptor Activity Pathway antibodies	Coregulation Of Androgen Receptor Activity Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Myogenesis Pathway antibodies	Myogenesis Pathway Diagram
Neural Crest Differentiation Pathway antibodies	Neural Crest Differentiation Pathway Diagram
Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies	Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
Wnt Signaling Pathway NetPath antibodies	Wnt Signaling Pathway NetPath Diagram

Diseases associated with TCF4 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>446 publications with TCF4 and Neoplasms
Nervous System Diseases Antibodies	>63 publications with TCF4 and Nervous System Diseases
Liver Neoplasms Antibodies	>45 publications with TCF4 and Liver Neoplasms
Liver Diseases Antibodies	>41 publications with TCF4 and Liver Diseases
Pitt-Hopkins syndrome Antibodies	>38 publications with TCF4 and Pitt-Hopkins syndrome
Breast Neoplasms Antibodies	>38 publications with TCF4 and Breast Neoplasms
Carcinoma, Hepatocellular Antibodies	>35 publications with TCF4 and Carcinoma, Hepatocellular
Cardiovascular Diseases Antibodies	>31 publications with TCF4 and Cardiovascular Diseases
Neoplasms, Experimental Antibodies	>28 publications with TCF4 and Neoplasms, Experimental
Inflammation Antibodies	>23 publications with TCF4 and Inflammation

Organs/Tissues associated with TCF4 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>137 publications with TCF4 and Blood
Intestine Antibodies	>112 publications with TCF4 and Intestine
Nerve Antibodies	>96 publications with TCF4 and Nerve
Brain Antibodies	>89 publications with TCF4 and Brain
Liver Antibodies	>80 publications with TCF4 and Liver
Embryonic Tissue Antibodies	>68 publications with TCF4 and Embryonic Tissue
Pancreas Antibodies	>66 publications with TCF4 and Pancreas
Muscle Antibodies	>47 publications with TCF4 and Muscle
Kidney Antibodies	>41 publications with TCF4 and Kidney
Lung Antibodies	>34 publications with TCF4 and Lung