Rat TACR1 Recombinant Protein – Cat# MBS968246

Substance-P Receptor (TACR1) Rat Recombinant Protein

Name: TACR1 Recombinant Protein; Substance-P Receptor; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS968246
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS968246

MBS968246 is a recombinant protein targeting Tacr1. Also known as Recombinant Rat Substance-P receptor (Tacr1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Substance-P receptor (Tacr1), Recombinant Protein

Full Product Name

Recombinant Rat Substance-P receptor (Tacr1)

Product Gene Name

Tacr1 recombinant protein

Product Synonym Gene Name

Tacr1; Tac1r

Product Synonym Names

Recombinant Substance-P receptor (Tacr1); Substance-P receptor; SPR; NK-1 receptor; NK-1R Tachykinin receptor 1

Sequence

MDNVLPMDSD LFPNISTNTS ESNQFVQPTW QIVLWAAAYT VIVVTSVVGN VVVIWIILAH KRMRTVTNYF LVNLAFAEAC MAAFNTVVNF TYAVHNVWYY GLFYCKFHNF FPIAALFASI YSMTAVAFDR YMAIIHPLQP RLSATATKVV IFVIWVLALL LAFPQGYYST TETMPSRVVC MIEWPEHPNR TYEKAYHICV TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV SAKRKVVKMM IVVVCTFAIC WLPFHVFFLL PYINPDLYLK KFIQQVYLAS MWLAMSSTMY NPIIYCCLND RFRLGFKHAF RCCPFISAGD YEGLEMKSTR YLQTQSSVYK VSRLETTIST VVGAHEEEPE EGPKATPSSL DLTSNGSSRS NSKTMTESSS FYSNMLA

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

46,366 Da

Sequence Positions

1-407

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 4; NC_005103.3 (177782964..177783356). Location: 4q34

3D Structure

ModBase 3D Structure for P14600

Species

Rattus norvegicus (Rat)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Tacr1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Tacr1. It may not necessarily be applicable to this product.

NCBI GI #

6981628

NCBI GeneID

24807

NCBI Accession #

NP_036799.1

UniProt Primary Accession #

P14600

UniProt Related Accession #

P14600

GenBank Nucleotide #

NM_012667.2

NCBI Official Full Name

substance-P receptor

NCBI Official Synonym Full Names

tachykinin receptor 1

NCBI Official Symbol

Tacr1

NCBI Official Synonym Symbols

Tac1r

UniProt Protein Name

Substance-P receptor

UniProt Synonym Protein Names

NK-1 receptor; NK-1R; Tachykinin receptor 1

Protein Family

Substance-P receptor

UniProt Gene Name

Tacr1

UniProt Synonym Gene Names

Tac1r; SPR; NK-1R

UniProt Entry Name

NK1R_RAT

NCBI Protein Information

substance-P receptor; SPR; NK-1R; NK-1 receptor; substance p receptor; neurokinin 1 receptor

NCBI Summary for Tacr1

mediates neuropeptide signaling; may play a role in pain sensitivity; may mediate baroreflex transmission for blood pressure regulation [RGD, Feb 2006]

UniProt Comments for Tacr1

TACR1: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: cell surface; dendrite; cytoplasm; integral to membrane; plasma membrane

Molecular Function: substance P receptor activity

Biological Process: response to nicotine; tachykinin signaling pathway; positive regulation of leukocyte migration; response to hormone stimulus; response to morphine; response to pain; sensory perception of pain; positive regulation of saliva secretion; response to organic cyclic substance; response to estradiol stimulus; elevation of cytosolic calcium ion concentration; behavioral response to pain; regulation of smooth muscle cell migration; learning and/or memory; neuropeptide signaling pathway; positive regulation of lymphocyte proliferation; regulation of blood pressure; positive regulation of stress fiber formation; positive regulation of action potential; response to electrical stimulus; angiotensin mediated drinking behavior; associative learning; positive regulation of synaptic transmission, cholinergic; regulation of smooth muscle cell proliferation; eating behavior; positive regulation of hormone secretion; positive regulation of synaptic transmission, GABAergic; positive regulation of ossification; positive regulation of vascular permeability; response to ethanol; long-term memory; response to heat; smooth muscle contraction involved in micturition; response to ozone; operant conditioning; positive regulation of vasoconstriction; sperm ejaculation; response to progesterone stimulus; positive regulation of blood pressure; acute inflammatory response; positive regulation of epithelial cell proliferation

Research Articles on Tacr1

1. In acute necrotizing pancreatitis overexpression of NK-1R contributes to disturbance of neuropeptides loop, resulting in aggregation of neutrophilic granulocyte sand promoting deterioration of lung injury.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Tacr1 recombinant protein

Products by Pathway	Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Measles Pathway antibodies	Measles Pathway Diagram
Measles Pathway antibodies	Measles Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with Tacr1 recombinant protein

Disease Name	Pubmed Publications
Pain Antibodies	>548 publications with Tacr1 and Pain
Nervous System Diseases Antibodies	>532 publications with Tacr1 and Nervous System Diseases
Inflammation Antibodies	>506 publications with Tacr1 and Inflammation
Vomiting Antibodies	>222 publications with Tacr1 and Vomiting
Neoplasms Antibodies	>177 publications with Tacr1 and Neoplasms
Neurogenic Inflammation Antibodies	>162 publications with Tacr1 and Neurogenic Inflammation
Hyperalgesia Antibodies	>160 publications with Tacr1 and Hyperalgesia
Sensation Disorders Antibodies	>116 publications with Tacr1 and Sensation Disorders
Brain Diseases Antibodies	>115 publications with Tacr1 and Brain Diseases
Edema Antibodies	>103 publications with Tacr1 and Edema

Organs/Tissues associated with Tacr1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>1063 publications with Tacr1 and Brain