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Dopamine Beta-Hydroxylase (DBH) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS968289

MBS968289 is a recombinant protein targeting DBH. Also known as Recombinant Human Dopamine beta-hydroxylase (DBH). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. Conversion of dopamine to noradrenaline. More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Dopamine beta-hydroxylase (DBH), Recombinant Protein
Full Product Name
Recombinant Human Dopamine beta-hydroxylase (DBH)
Product Gene Name
DBH recombinant protein
Product Synonym Gene Name
DBH
Product Synonym Names
Recombinant Dopamine beta-hydroxylase (DBH); Dopamine beta-hydroxylase EC= 1.14.17.1; Dopamine beta-monooxygenase Cleaved into the following chain: 1. Soluble dopamine beta-hydroxylase
Sequence
SAPRESPLPY HIPLDPEGSL ELSWNVSYTQ EAIHFQLLVR RLKAGVLFGM SDRGELENAD LVVLWTDGDT AYFADAWSDQ KGQIHLDPQQ DYQLLQVQRT PEGLTLLFKR PFGTCDPKDY LIEDGTVHLV YGILEEPFRS LEAINGSGLQ MGLQRVQLLK PNIPEPELPS DACTMEVQAP NIQIPSQETT YWCYIKELPK GFSRHHIIKY EPIVTKGNEA LVHHMEVFQC APEMDSVPHF SGPCDSKMKP DRLNYCRHVL AAWALGAKAF YYPEEAGLAF GGPGSSRYLR LEVHYHNPLV IEGRNDSSGI RLYYTAKLRR FNAGIMELGL VYTPVMAIPP RETAFILTGY CTDKCTQLAL PPSGIHIFAS QLHTHLTGRK VVTVLVRDGR EWEIVNQDNH YSPHFQEIRM LKKVVSVHPG DVLITSCTYN TEDRELATVG GFGILEEMCV NYVHYYPQTQ LELCKSAVDA GFLQKYFHLI NRFNNEDVCT CPQASVSQQF TSVPWNSFNR DVLKALYSFA PISMHCNKSS AVRFQGEWNL QPLPKVISTL EEPTPQCPTS QGRSPAGPTV VSIGGGKG
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
66.9 kDa
Sequence Positions
40-617aa; Partial(Soluble dopamine beta-hydroxylase Chain)
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 9; NC_000009.11 (136501485..136524466). Location: 9q34
OMIM
223360
3D Structure
ModBase 3D Structure for P09172
Species
Homo sapiens (Human)

Product Categories/Family for DBH recombinant protein

Neuroscience
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-PAGE of DBH recombinant protein

Human DBH Recombinant Protein – Cat# MBS968289

Other Notes

Small volumes of DBH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DBH. It may not necessarily be applicable to this product.

NCBI GI #
116534900
NCBI GeneID
1621
NCBI Accession #
NP_000778.3
UniProt Primary Accession #
P09172
UniProt Secondary Accession #
Q5T381; Q96AG2
UniProt Related Accession #
P09172
GenBank Nucleotide #
NM_000787.3
NCBI Official Full Name
dopamine beta-hydroxylase
NCBI Official Synonym Full Names
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
NCBI Official Symbol
DBH
NCBI Official Synonym Symbols
DBM
UniProt Protein Name
Dopamine beta-hydroxylase
UniProt Synonym Protein Names
Dopamine beta-monooxygenase
Protein Family
Dopamine beta-hydroxylase
UniProt Gene Name
DBH
UniProt Entry Name
DOPO_HUMAN
NCBI Protein Information
dopamine beta-hydroxylase

NCBI Summary for DBH

The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq, Jul 2008]
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UniProt Comments for DBH

DBH: Conversion of dopamine to noradrenaline. Homotetramer composed of two non-covalently bound disulfide-linked dimers. Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids. Belongs to the copper type II ascorbate-dependent monooxygenase family.

Protein type: EC 1.14.17.1; Motility/polarity/chemotaxis; Cell cycle regulation; Amino Acid Metabolism - tyrosine; Oxidoreductase; Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: membrane; cytoplasm; integral to membrane; extracellular region

Molecular Function: copper ion binding; L-ascorbic acid binding; dopamine beta-monooxygenase activity; catalytic activity

Biological Process: fear response; dopamine catabolic process; maternal behavior; response to amphetamine; cytokine production; locomotory behavior; response to pain; behavioral response to ethanol; leukocyte mediated immunity; glucose homeostasis; memory; regulation of cell proliferation; norepinephrine biosynthetic process; synaptic transmission; catecholamine biosynthetic process; homoiothermy; positive regulation of vasoconstriction; visual learning; blood vessel remodeling; leukocyte migration

Disease: Dopamine Beta-hydroxylase Deficiency, Congenital
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Research Articles on DBH

1. This study shows that Dopamine beta hydroxylase (DBH) rs5320 polymorphism influences nicotine dependence.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with DBH recombinant protein

 Products by Pathway  Pathway Diagram
 Amine-derived Hormones Pathway antibodies  Amine-derived Hormones Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Catecholamine Biosynthesis Pathway antibodies  Catecholamine Biosynthesis Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Monoamine Transport Pathway antibodies  Monoamine Transport Pathway Diagram
 Tyrosine Metabolism Pathway antibodies  Tyrosine Metabolism Pathway Diagram
 Tyrosine Metabolism Pathway antibodies  Tyrosine Metabolism Pathway Diagram

Diseases associated with DBH recombinant protein

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >214 publications with DBH and Mental Disorders
 Nervous System Diseases Antibodies  >194 publications with DBH and Nervous System Diseases
 Vascular Diseases Antibodies  >122 publications with DBH and Vascular Diseases
 Hypertension Antibodies  >92 publications with DBH and Hypertension
 Neoplasms Antibodies  >80 publications with DBH and Neoplasms
 Movement Disorders Antibodies  >52 publications with DBH and Movement Disorders
 Mood Disorders Antibodies  >48 publications with DBH and Mood Disorders
 Heart Diseases Antibodies  >40 publications with DBH and Heart Diseases
 Basal Ganglia Diseases Antibodies  >40 publications with DBH and Basal Ganglia Diseases
 Hypotension Antibodies  >40 publications with DBH and Hypotension

Organs/Tissues associated with DBH recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >506 publications with DBH and Brain
 Nerve Antibodies  >362 publications with DBH and Nerve
 Adrenal Gland Antibodies  >214 publications with DBH and Adrenal Gland
 Ganglia Antibodies  >149 publications with DBH and Ganglia
 Embryonic Tissue Antibodies  >26 publications with DBH and Embryonic Tissue
 Mouth Antibodies  >15 publications with DBH and Mouth
 Testis Antibodies  >7 publications with DBH and Testis
 Lymph Node Antibodies  >5 publications with DBH and Lymph Node
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