RAD17 Antibody – Rabbit Polyclonal

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]

RAD17: a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. Shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. Binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. Phosphorylated and activated after DNA damage, inducing cell cycle G2 arrest. Eight alternatively spliced variants have been reported.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 5q13

Cellular Component: chromosome, telomeric region; nucleoplasm; nucleus

Molecular Function: ATP binding; DNA clamp loader activity; protein binding

Biological Process: DNA damage checkpoint; DNA repair; DNA replication; DNA replication checkpoint; double-strand break repair; double-strand break repair via homologous recombination; mitotic cell cycle checkpoint; negative regulation of DNA replication; regulation of phosphorylation; response to DNA damage stimulus