COX11 Antibody – Rabbit Polyclonal

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. [provided by RefSeq, Jun 2009]

COX11: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. Belongs to the COX11/CtaG family.

Protein type: Mitochondrial; Energy Metabolism - oxidative phosphorylation; Oxidoreductase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrion

Molecular Function: copper ion binding; cytochrome-c oxidase activity; electron carrier activity

Biological Process: negative regulation of glucokinase activity; respiratory chain complex IV assembly; respiratory gaseous exchange