SEC31A Antibody – Rabbit Polyclonal

The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

SEC31A: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. Interacts with PDCD6 in a calcium-dependent manner. Interacts with KLHL12. Abundantly and ubiquitously expressed. Belongs to the WD repeat SEC31 family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; Oncoprotein

Chromosomal Location of Human Ortholog: 4q21.22

Cellular Component: COPII vesicle coat; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; ER to Golgi transport vesicle; Golgi membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm

Molecular Function: calcium-dependent protein binding; protein binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine; protein transport; response to calcium ion; unfolded protein response