Beta-2 Adrenergic Receptor (ADRB2) Antibody – Rabbit Polyclonal

ADRB2: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Cellular Component: apical plasma membrane; axon; caveola; cytoplasm; dendrite; dendritic spine; early endosome; endosome; integral to plasma membrane; intracellular membrane-bound organelle; membrane; nucleus; plasma membrane; receptor complex; sarcolemma

Molecular Function: adenylate cyclase binding; B2 bradykinin receptor binding; beta2-adrenergic receptor activity; dopamine binding; drug binding; enzyme binding; epinephrine binding; G-protein alpha-subunit binding; ionotropic glutamate receptor binding; norepinephrine binding; PDZ domain binding; potassium channel regulator activity; protein binding; protein complex binding; protein homodimerization activity

Biological Process: adenylate cyclase activation; aging; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; associative learning; bone resorption; brown fat cell differentiation; diaphragm contraction; diet induced thermogenesis; female pregnancy; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase activating pathway; heat generation; liver development; negative regulation of angiogenesis; negative regulation of inflammatory response; negative regulation of multicellular organism growth; negative regulation of ossification; negative regulation of smooth muscle contraction; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of apoptosis; positive regulation of ATPase activity; positive regulation of bone mineralization; positive regulation of cell proliferation; positive regulation of heart contraction; positive regulation of MAPKKK cascade; positive regulation of potassium ion transport; positive regulation of protein ubiquitination; positive regulation of skeletal muscle growth; positive regulation of the force of heart contraction by epinephrine; positive regulation of transcription from RNA polymerase II promoter; positive regulation of vasodilation; receptor-mediated endocytosis; regulation of calcium ion transport; regulation of excitatory postsynaptic membrane potential; regulation of sensory perception of pain; regulation of sodium ion transport; regulation of systemic arterial blood pressure by norepinephrine-epinephrine; regulation of vasodilation; response to cold; response to estrogen stimulus; response to hypoxia; response to progesterone stimulus; response to testosterone stimulus; synaptic transmission, glutamatergic; wound healing